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医之本

彩虹医学 首页 专家团队
蔡国平 职称:助理教授 擅长:细胞病理学 单位:耶鲁大学医学院 病理科

2005-2006 细胞病理学进修学习,纽约大学医学院病理科,纽约州纽约市。2001-2005 解剖和临床病理住院医师,纽约大学医学院病理科,纽约州纽约市
1997-1999 博士后学习,德雷克塞尔大学医学院(原宾西法尼亚医学院-哈内曼大学), 参与国家卫生研究院(NIH)博士后培训项目—衰老的分子和细胞机制,宾夕法尼亚州费城市
1993-1997 博士后学习及助理研究员,德雷克塞尔大学医学院药理系,宾夕法尼亚州费城市
1985-1988 病理生理学硕士研究生,温州医学院,中国浙江温州市
1978-1983 医学生,温州医学院,中国浙江温州市
工作经历:
2009-至今 助理教授,耶鲁大学医学院病理系,美国康涅狄格州纽黑文市
2006-2009 助理教授,匹兹堡大学医学院病理系,美国宾夕法尼亚州匹兹堡市
1999-2001 研究助理教授,德雷克塞尔大学医学院药理学和生理学系,美国宾夕法尼亚州费城市
1990-1992 副主任,温州医学院肺心病研究室,中国浙江温州市
1988-1992 讲师,温州医学院病理生理学系,中国浙江温州市
1983-1985 助教,温州医学院病理生理学系,中国浙江温州市
教学经历:
2009-至今 助理教授,耶鲁大学医学院病理系,康涅狄格州纽黑文市
2006-2009 助理教授,匹兹堡大学医学院病理系,宾夕法尼亚州匹兹堡市
2002-2004 教学助理,纽约大学医学院,纽约州纽约市
1999-2001 导师,德雷克塞尔大学医学院药理学和生理学系博士课程,宾夕法尼亚州费城市
1988-1992 讲师,温州医学院病理生理学系,中国浙江温州市
1983-1985 助教,温州医学院病理生理学系,中国浙江温州市
专业资格认证:
2005 美国病理学委员会,解剖与临床病理学证书
2006 美国病理学委员会,细胞病理学证书
2005 纽约州行医执照
2006 宾夕法尼亚州行医执照
2009 康涅狄格州行医执照
荣誉和奖励:
2009 美国和加拿大病理学会斯托韦尔-奥比森优异奖(参与作者)
2009 美国和加拿大病理学会外科病理学奖(参与作者)
2009 国际泌尿病理学会研究奖(参与作者)
2008 巴氏细胞病理学协会研究奖(资深作者)
1997 美国老龄协会格林博士后比赛奖
行政和社会活动:
2009-至今 巴氏细胞病理学协会,教育和培训专责小组成员
2008-2009 轮值主任,匹兹堡大学医学院-谢迪赛德医院负责病理住院医师和研修计划,宾夕法尼亚州匹兹堡市
2008-2009 匹兹堡大学医学院病理科,住院医师咨询委员会顾问,宾夕法尼亚州匹兹堡市
2004-2005 纽约大学医学院病理科,住院医师咨询委员会顾问,纽约州纽约市
2003-2005 纽约大学医学院住院医师理事会委员,纽约州纽约市
专业期刊审稿:
Cancer Cytopathology
Diagnostic Cytopathology
Acta Cytologica
CytoJournal
Archives of Pathology & Laboratory Medicine
Journal of Translational Medicine
Journal of the Pancreas
Cancer Biology & Therapy
World Journal of Surgical Oncology
专业学会会员:
美国和加拿大病理学会
美国病理学院
美国细胞病理学协会
巴氏细胞病理学协会
出版物:
Book Chapters
1. Cai G.Breast. In:The Year Book of Pathology and Laboratory Medicine, 2008 (Raab SS and Parwani AV, eds.).Philadelphia: Elsevier Mosby, 2008: p23-p45.
2. Cai G, Wang HY, Friedman E. Adenosine-mediated regulation of cardiac function: The effect of age.In: Effects of Extracellular Adenosine and ATP on Cardiomyocytes (Pelleg A, ed.).Georgetown: Landes Biosciences, 1998: p173-p195.
Original Peer-Reviewed Articles
1. Nagarajan P,Cai G,Padda MS, Selbst M, Kowalski D, Proctor DD, Chhieng D, Aslanian HR, Harigopal M.Littoral cell angioma of the spleen diagnosed by endoscopic ultrasound-guided fine-needle aspiration biopsy.Diagnostic Cytopathology(Published Online: May 14, 2010).
2. Cai G,Teot LA, Khalbuss WE, Yu J, Monaco SE, Jukic DM, Parwani AV. Cytologic evaluation of image-guided fine needle aspiration biopsies via robotic microscopy: A validation study.Journal of Pathology Informatics2010; 1:4.
3. Marks-Jones DA, Zynger DL, Parwani AV,Cai G.Fine needle aspiration biopsy of renal mucinous tubular and spindle cell carcinoma: Report of two cases.Diagnostic Cytopathology2010; 38(1): 51-55.
4. Monaco SE, Teot LA, Felgar RE, Surti U,Cai G.Fluorescence in situ hybridization studies on direct smears: an approach to enhance the fine-needle aspiration biopsy diagnosis of B-cell non-Hodgkin lymphomas.Cancer Cytopathology2009; 117(5): 338-348.
5. Yu J, Nikiforova MN, Hodak SP, Yim JH,Cai G,Walls A, Nikiforov YE, Seethala RR. Tumor-to-tumor Metastases to Follicular Variant of Papillary Thyroid Carcinoma: Histologic, Immunohistochemical, and Molecular Studies of Two Unusual Cases.Endocrine Pathology2009; 20(4): 235-242.
6. Yu J, Seethala RR, Walls A,Cai G.Fine-needle aspiration of breast carcinoma metastatic to follicular variant of papillary thyroid carcinoma.Diagnostic Cytopathology2009; 37(9): 665-666.
7. Monaco SE, Navolotskaia O,Cai G.Fine-needle aspiration biopsy diagnosis of prostate carcinoma metastatic to the breast.Diagnostic Cytopathology2009; 37(5): 388-390.
8. Ramdall RB, Wallach RC, Cangiarella J,Cai G,Elgert P, Simsir A, Levine P. Origin, frequency and clinical significance of glandular cells in liquid-based pap tests from patients posthysterectomy.Acta Cytologica2009; 53(1): 1-9.
9. Cai G, Ramdall RB, Levine P, Yang GC. Fine-needle aspiration of metastatic prostatic neuroendocrine carcinomas: cytomorphologic and immunophenotypic features.Diagnostic Cytopathology2008; 36(8):545-549.
10. Cai G, Parwani AV. Cytomorphology of lymphoepithelioma-like carcinoma of the urinary bladder: report of two cases.Diagnostic Cytopathology2008; 36(8):600-603.
11. Cai G, Levine P, Sen F. Diagnosis of myeloid sarcoma involving salivary glands by fine-needle aspiration cytology and flow cytometry: Report of four cases.Diagnostic Cytopathology2008; 36(2):124-127.
12. Elwood H, Parwani A,Cai G. Fine-needle aspiration biopsy of myxoid liposarcoma metastatic to the liver: cytomorphologic and cytogenetic features.Diagnostic Cytopathology2007; 35(11):734-737.
13. Cai G, Ramdall R, Garcia R, Levine P. Pulmonary metastasis of giant cell tumor of the bone diagnosed by fine-needle aspiration biopsy.DiagnosticCytopathology2007; 35(6): 358-362.
14. Cai G,Mercado C, Cangiarella J. Adenomyoepithelioma of the breast: diagnosed by fine-needle aspiration biopsy.ASCP Check Sample Cytopathology2007; 35(2): 17-30.
15. Ramdall RB, Alasio TM,Cai G,Yang GC. Primary vascular neoplasms unique to the spleen: Littoral cell angioma and splenic hamartoma diagnosis by fine-needle aspiration biopsy.Diagnostic Cytopathology2007; 35: 137-142.
16. Cai G,Sidhu GS, Gu X, Herrera GA, Cubukcu-Dimopulo O, Kahn T, Wieczorek R. Plasma cell dyscrasia with kappa light chain crystals in proximal tubular cells: a histological immunofluorescent and ultrastructural study.Ultrastructural Pathology2006; 30: 315-319.
17. Ramdall RB,Cai G,Alasio TM, Levine P. Fine-needle aspiration biopsy for the primary diagnosis of lymphoproliferative disorders involving the spleen: One institution's experience and review of the literature.Diagnostic Cytopathology2006; 34: 812-817.
18. Ramdall RB,Cai G, Levine PH, Bhanote M, Garcia R, Cangiarella J. Fine-needle aspiration biopsy findings in epithelioid myoepithelioma of the parotid gland: a case report.Diagnostic Cytopathology2006; 34: 776-779.
19. Cai G,Inghirami G, Moreira A, Sen F.Primary hepatic anaplastic large cell lymphoma diagnosed by fine needle aspiration biopsy.Diagnostic Cytopathology2005; 33: 106-109.
20. Cai G,Huang H, Shapiro E, Zhou H,Yeh S, Melamed J, Greco MA, Lee P. Expression of androgen receptor-associated protein 55 (ARA55) in the developing human fetal prostate.Journal of Urology2005; 173: 2190-2193.
21. Velazquez EF, Soskin A, Bock A, Codas R,Cai G, Barreto JE, Cubilla AL. Epithelial abnormalities and precancerous lesions of anterior urethra in patients with penile carcinoma: a report of 89 cases.Modern Pathology2005; 18: 917-923.
22. Cai G,Simsir A, Cangiarella J. Invasive mammary carcinoma with osteoclast-like giant cells diagnosed by fine needle aspiration biopsy: review of the cytologic literature and distinction from other mammary lesions containing giant cells.Diagnostic Cytopathology2004; 30: 396-400.
23. Jin LQ, Goswami S,Cai G,Zhen X, Friedman E. SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain.Journal of Neurochemistry2003; 85: 378-386.
24. Zhen X, Torres C,Cai G, Friedman E. Inhibition of protein tyrosine/mitogen-activated protein kinase phosphatase activity is associated with D2 dopamine receptor supersensitivity in a rat model of Parkinson's disease.Molecular Pharmacology2002; 62(6): 1356-1363.
25. Cai G, Wang HY, Friedman E. Increased dopamine receptor signaling and dopamine receptor-G protein coupling in denervated striatum.Journal of Pharmacology and Experimental Therapeutics2002; 302(3): 1105-1112.
26. Tilakaratne N,Cai G, Friedman E. Attenuation of cocaine-induced genomic and functional responses in prenatal cocaine-exposed rabbits.Pharmacology, Biochemistry and Behavior2001; 69: 225-232.
27. Seasholtz TM,Cai G,Wang HY, Friedman E. Effects of ischemia-reperfusion on vascular contractility and a1adrenergic receptor signaling in the rat tail artery.Journal of Applied Physiology2001; 91: 1004-1010.
28. Gao F, Christopher TA, Lopez BL, Friedman E,Cai G, Ma XL. Mechanism of decreased adenosine protection in reperfusion injury of aging rats.American Journal of Physiology Heart & Circulatory Physiology2000; 279: H329-H338.
29. Cai G, Zhen X, Uryu K, Friedman E. D2dopamine receptor-mediated activation of extracellular signal-regulated protein kinase is required for sensitized locomotive response in 6-hydroxydopamine-lesioned rats.Journal of Neuroscience2000; 20: 1849-1857.
30. Zhen X, Uryu K,Cai G, Johnson GP, and Friedman E. Age-associated impairment in brain MAPK signal pathways and the effect of caloric restriction in Fischer 344 rats.Journal of Gerontology1999; 54A: B539-B548.
31. Cai G, Gurdal H, Wang HY, Smith C, Friedman E. Inverse agonist properties of dopaminergic antagonists at the D1Adopamine receptor: uncoupling of the D1Adopamine receptor from its associated Gs protein.Molecular Pharmacology1999; 56: 989-996.
32. Jin LQ,Cai G, Wang HY, Smith C, Friedman E. Characterization of the phosphoinositide-linked dopamine receptor in a mouse hippocampal-neuroblastoma hybrid cell line.Journal of Neurochemistry1998; 71: 1935-1943.
33. Gao E, Snyder DL, Roberts J, Friedman E,Cai G, Pelleg A, Horwitz J. Age-related decline in adenosine A1receptor function in the heart is attenuated by dietary restriction.Journal of Pharmacology and Experimental Therapeutics1998; 285: 186-192.
34. Tilakaratne N,Cai G, Friedman E. Cocaine-induced activation of c-fos gene expression is attenuated in prenatal cocaine-exposed rabbits.Annals of New York Academy of Science1998; 846: 368-370.
35. Cai G, Wang HY, Gao E, Horwitz J, Snyder DL, Pelleg A, Roberts J, Friedman E. Reduced adenosine A1receptor-Gas protein coupling in ventricular myocardium during aging.Circulation Research1997; 81: 1065-1071.
36. Seasholtz TM, Gurdal H, Wang HY,Cai G, Johnson MD, Friedman E. Heterologous desensitization of the rat-tail artery contraction and inositol phosphate accumulation following in vitro exposure to phenylnephrine is mediated by decreased levels of Gaq and Gai.Journal of Pharmacology and Experimental Therapeutics1997; 283: 925-931.
37. Friedman E, Jin LQ,Cai G, Hollon TR, Drago J, Sibley DR, Wang HY. D1-like dopaminergic activation of phosphoinositide hydrolysis is independent of D1A dopamine receptors: evidence from D1A knockout mice.Molecular Pharmacology1997; 51(1):6-11.
38. Stuliff RL,Cai G, Gurdal H, Snyder DL, Roberts J, Johnson MD. Cardiovascular hypertrophy and increased vascular response following repeated cocaine administration in rabbits.Life Science1996; 58: 675-682.
39. Gurdal H,Cai G,Johnson MD. Alpha-1 adrenoceptor responsiveness in the aging aorta.European Journal of Pharmacology1995; 274: 117-123.
40. Cai G, Gurdal H, Seasholtz TM, Johnson MD. Age-related changes in angiotensin II-stimulated vascular contraction and inositol phosphate accumulation in F344 rats.Mechanism of Ageing & Development1994; 76: 125-133.
41. Johnson MD, Gurdal H,Cai G, Snyder DL, Roberts J. Prenatal cocaine exposure affects the development of aortic adrenergic innervation and contractile responses.Life Science1994; 55: 1327-1335.
42. Cai G, Bao Y, Xu Z, Jiang Z, Chen M. Effect of chronic normobaric anoxia and hypercapnia on the density of pulmonary beta-adrenoceptors in rats.Journal of Wenzhou Medical College1993; 23: 6-9.
43. Bao Y,Cai G. Observation on nailfold microcirculation in patients with alopecia.Zhejinag Journal of Medicine1993; 15: 42-44.
44. Liu F, Lan Y,Cai G,Cheng S. Assessment of induced-noninvasively postextrasystolic potentiation on right ventricular function in patients with cor pulmonale.Chinese Journal of Tuberculosis and Respiratory Disease1991; 14: 280-282.
45. Liu F, Lan Y,Cai G, Cheng S. Clinical study on the method of measuring cardiac function curve.Chinese Journal of Cardiology1991; 19: 243-245.
46. Cai G, Liu F, Jiang Z, Cai K, Xu Z. Detection of postextrasystolic potentiation with differential impedance cardiogram.Journal of Wenzhou Medical College1991; 21: 200-204.
47. Lan Y, Liu F, Cheng S,Cai G, Bao M. Clinical study of postextrasystolic potentiation in patients with myocardiopathy and myocarditis.Journal of Wenzhou Medical College1991; 21: 195-199.
48. Cai G, Bao Y, Cai K, Jiang Z, Yu H. Change and significance of pulmonary hemodynamics before and after exercise in patients with cor pulmonale.Journal of Wenzhou Medical College1991; 21: 65-68.
49. Cai G, Liu F, Jiang Z, Cai K, Xu Z. An evaluation of cardiac contractility with the postextrasystolic potentiation.Journal of Wenzhou Medical College1990; 20: 193-197.
50. Liu F, Lan Y, Cheng S,Cai G. Assessment of left diastolic function by the postextrasystolic atrial wave change of the differential impedance cardiogram.Journal of Wenzhou Medical College1990; 20: 129-133.
51. Yu H, Xu Z, Liu S,Cai G, Gong Y. Clinical evaluation of using postexercise right ventricular systolic time interval to diagnose cor pulmonale.Zhejiang Journal of Medicine1989; 11: 2-5.
52. Yu H, Gong Y,Cai G. Simultaneous observation on nailfold microcirculation and pulmonary artery pressure in patients with cor pulmonale.Journal of Wenzhou Medical College1989; 19: 10-13.
Abstracts & Presentations
1. Wu Y, Chhieng D, Bao Y,Cai G.Expression of neuroD and CD44 in the fine needle aspirates of pancreatic endocrine neoplasms.Presented at the USCAP Annual Meting, San Antonio, Texas, 2011.
2. Levy G, Theoharis C, Chhieng D, Materin M,Cai G.Fine needle aspiration biopsy of the eye: a single institution's experience.Presented at the USCAP Annual Meting, San Antonio, Texas, 2011.
3. Kamat SN, Monaco SE, Pantanowitz L, Khalbuss W,Cai G, Parwani AV.Utility of Molecular testing in fine needle aspiration and needle core biopsy diagnosis of renal mass lesions.Presented at the USCAP Annual Meting, San Antonio, Texas, 2011.
4. Cai G, Puchalski JT, Chhieng D. Diagnosis of mediastinal granulomas by endobronchial ultrasound-guided fine needle aspiration biopsy (EBUS-FNAB).Presented at the International Academy of Pathology Annual Meeting, Sao Paulo, Brazil, 2010.
5. Selbst M, Chhieng D,Cai G.DOG1 expression in the fine needle aspirates of gastrointestinal stromal tumors.Presented at the 17th International Congress of Cytology, Edinburgh, Scotland, 2010.
6. Cai G,Siddiqui U, Aslanian H, Finkelstein A, Schofield K, Chhieng.Molecular analysis of pancreatic cyst fluid: correlation with cytologic diagnosis and surgical follow-up. Presented at the USCAP Annual Meting, Washington, DC, 2010.
7. Cai G,Zynger DL, Marks-Jones D, Parwani AV. On-site cytological evaluation and complementary needle core biopsy enhance fine needle aspiration diagnosis of renal lesions.Presented at the ASC Annual Meeting, Denver, Colorado, 2009.
8. Cai G,Jamidar P, Finkelstein A, Schofield K, Chhieng D. Diagnostic value of combined brush cytology and biopsy for bile duct lesions: A retrospective review of 103 concurrent specimens.Presented at the ASC Annual Meeting, Denver, Colorado, 2009.
9. Marks-Jones D, Teot LA, Khalbuss WE,Cai G. Rapid on-site evaluation in the endobronchial ultrasound-guided fine needle aspiration biopsy of mediastinal lymph nodes.Presented at the USCAP Annual Meeting, Boston, Massachusetts, 2009.
10. Bansal M,Cai G, Khalbuss WE.The contribution of fluorescence in-situ hybridization (FISH) studies to the fine-needle aspiration biopsy (FNAB) of soft tissue and bone neoplasms. Presented at the USCAP Annual Meeting, Boston, Massachusetts, 2009.
11. Niemeier LA, Cieply K, Dhir R, Parwani AV, Cumbie K, Sherer C, Salvatore J, Youschak M, Perepletchikov A,Cai G, Kiss L, Bastacky SI.Fluorescence in situ hybridization (FISH) assay for ERG gene disruption in acinar (PCA-A) and ductal (PCA-D) subtypes of prostatic adenocarcinoma.Presented at the USCAP Annual Meeting, Boston, Massachusetts, 2009.
12. Zynger DL, LaFramboise WA, Krill-Burger JM, Sciulli CM, Hensler AM, Perepletchikov AM, Kiss LP, Dhir R,Cai G, Parwani AV, Bastacky SI.MicroRNA Expression profiling distinguishes conventional and chromophobe renal cell carcinomas from normal renal parenchyma.Presented at the USCAP Annual Meeting, Boston, Massachusetts, 2009.
13. Dvorakova M, Dhir R, Bastacky SI,Cai G, Khalbuss WE, Acquafondata MB, Parwani AV.Utility of double immunohistochemical staining for smoothelin/pancytokeratin in the staging of urothelial uarcinomas.Presented at the USCAP Annual Meeting, Boston, Massachusetts, 2009.
14. Cai G, Khalbuss WE, Teot LA. Diagnostic values of endobronchial ultrasound-guided fine needle aspiration biopsy (EBUS-FNAB) in assessment of mediastinal lymphadenopathy.Presented at the International Academy of Pathology Annual Meeting, Athens, Greece, 2008.
15. Cai G, Monaco SE, Teot LA. Assessment of estrogen receptor (ER), progesterone receptor (PR) and Her2/neu status in fine needle aspirates of metastatic breast carcinomas. Presentedat the International Academy of Pathology Annual Meeting, Athens, Greece, 2008.
16. Monaco SE, Sherer M, Teot LA,Cai G. Fluorescence in-situ hybridization (FISH) studies on direct smears: an approach to enhance the fine needle aspiration biopsy diagnosis of B-cell non-Hodgkin lymphomas.Presented at the USCAP Annual Meeting, Denver, Colorado, 2008.
17. LaCaria TM, Teot LA,Cai G.Utility of glypican-3, alpha-fetoprotein, and HepPar-1 as a panel for detecting hepatocellular carcinoma in fine needle aspiration biopsies.Presented at the USCAP Annual Meeting, Denver, Colorado, 2008.
18. Cai G, Khalbuss WE, Yu J, Parwani AV, Jukic D, Teot LA.Cytological evaluation of image-guided fine needle aspiration biopsies via robotic microscopy: a pilot validation study.Presented at the USCAP Annual Meeting, Denver, Colorado, 2008.
19. Perepletchikov A, Dhir R, Parwani AV,Cai G, Bastacky S. Margin assessment of the radical prostatectomy (RP) utilizing a sectioning method that optimizes margin evaluation and permits tissue banking.Presented at the USCAP Annual Meeting, Denver, Colorado, 2008.
20. Bastacky S, Perepletchikov A, Parwani AV, Yin M,Cai G, Dhir R. Clinicopathologic features of hematolymphoid neoplasms (HLN) involving the prostate in surgical pathology specimens at the University of Pittsburgh.Presented at the USCAP Annual Meeting, Denver, Colorado, 2008.
21. Perepletchikov A, Parwani AV, Dhir R,Cai G, Yin M, Bastacky S. The incidence of lymphoma in pelvic lymph nodes (PLNs) in patients undergoing radical prostatectomy (RP).Presented at the USCAP Annual Meeting, Denver, Colorado, 2008.
22. Cai G, Grzybicki DM, Jensen CS, Zarbo RJ, Carter G, Raab SS. Should negative Pap tests be reviewed in patients with a newly diagnosed endometrial, cervical or vaginal adenocarcinoma?Presented at the USCAP Annual Meeting, San Diego, California, 2007.
23. Cai G, Simsir A, Yee H, Chiriboga L, Kefalides P, Cangiarella J. Differential expression of mucins, MIB-1 and p53 in mucinous tumors of the pancreas.Presented at the USCAP Annual Meeting, San Antonio, Texas, 2005.
24. Cai G, Witkiewicz A, Velazquea EF. E-cadherin expression in primary melanoma with and without sentinel lymph node metastasis.Presented at the USCAP Annual Meeting, San Antonio, Texas, 2005.
25. Velazquez EF, Barron LP,Cai G, Ma L, Reyes-Mugica M. Penile lichen sclerosus in children: its histology and immunophenotype.Presented at the Society for Pediatric Pathology Annual Meeting, San Antonio, Texas, 2005.
26. Cai G,Simsir A, Yee H, Chiriboga L, Cangiarella J. Combined use of MIB-1 and p53 immunostains in classification of pulmonary neuroendocrine tumors: an immuno-histochemical study on material obtained by fine needle aspiration biopsy (FNAB).Presented at the USCAP Annual Meeting, Vancouver, Canada, 2004.
27. Cai G,Huang H, Shapiro E, Zhou H,Yeh S, Melamed J, Lee P, Greco MA. Expression of androgen receptor-associated protein 55 (ARA55) in the developing human fetal prostate.Presented at the Society for Pediatric Pathology Annual Meeting, Vancouver, Canada, 2004.
28. Cai G,Sidhu GS, Gu X, Herrera GA, Cubukcu-Dimopulo O, Kahn T, Wieczorek R. Plasma cell dyscrasia with kappa light chain crystals in proximal tubular cells: a histological immunofluorescent and ultrastructural study.Presented at the Ultrapath XII, Barcelona, Spain, 2004.
29. Strauss RA, Gajera DA, Saladino M,Cai G, Zhu C, Afonja O, Moskowitz N, Shah S, Caprio M, Tropper P, Talebian S, Lee M. Management of an allo-anti-Rh17: mother and baby. Presented at the AABB Annual Meeting & TXPO, Baltimore, Maryland, 2004.
30. Cai G, Yacoub H, Ma XL, Friedman E. Nitric oxide mediates desensitization of myocardial A1 adenosine receptor.Presented at the Experimental Biology 2000, San Diego, California, 2000.
31. Cai G, Wang HY, Bhamre S, Friedman E. Enhanced D1dopamine receptor/G protein coupling in unilateral 6-hydroxydopamine-lesioned rats.Presented at the Society for Neuroscience 28thAnnual Meeting, Los Angeles, California, 1998.
32. Zhen X, Wang HY, Uryu K,Cai G, Smith C, Friedman E. Activation of extracellular signal-regulated kinase (ERK) by D4dopamine receptors requires Src, SHC-Grb2 via Gi protein.Presented at theSociety for Neuroscience 28thAnnual Meeting, Los Angeles, California, 1998.
33. Cai G, Zhen X, Friedman E. Dopamine receptor-mediated activation of MAP kinase is involved in quinpirole-induced rotational behavior in unilateral 6-hydroxydopamine-lesioned rats.Presented at the European Society for Neurochemistry, St. Petersburg, Russia, 1998.
34. Friedman E,Cai G, Ma XL, Wang HY. Reduced adenosine A1receptor and Ga protein coupling in rat ventricular myocardium during aging.Presented at the 6thInternational Symposium on Adenosine and Adenine Nucleotides,Ferra, Italy, 1998.
35. Cai G, Wang HY, Friedman E. Coupling of adenosine A1receptors to G proteins is reduced in the aged rat heart.Presented at the American Aging Association 12thAnnual Meeting, Philadelphia, Pennsylvania, 1997.
36. Zhen X, Uryu K,Cai G,Friedman E. MAPK pathway is impaired in aged brains of Fischer 344 rats.Presented at the American Aging Association 12thAnnual Meeting, Philadelphia, Pennsylvania, 1997.
37. Friedman E,Cai G, Gao E, Wang HY, Horwitz J, Pelleg A, Snyder DL, Roberts J. Reduced adenosine A1receptor coupling to G proteins in the ventricles of senescent rats.Presented at the American Heart Association 70thscientific Sessions, Orlando, Florida, 1997.
38. Gao E, Snyder DL, Friedman E,Cai G, Horwitz J, Roberts J. Age-related decline in adenosine A1receptor function in the heart is attenuated by dietary restriction.Presented at the Annual Meeting of American Gerontology Society,Cincinnati, Ohio, 1997.
39. Friedman E, Jin LQ,Cai G,Hollon TR, Drago J, Sibley DR, Wang HY. D1-like dopaminergic activation of phosphoinositol hydrolysis is independent of D1Adopamine receptors: Evidence from D1Aknockout mice.Presented at the 8thInternational Catecholamine Symposium,Los Angles, California, 1996.
40. Wang HY,Cai G, Friedman E. Dopamine D1receptors coupling to activation of adenylyl cyclase is mediated by Gs but not Golf proteins.Presented at theSociety for Neuroscience 25thAnnual Meeting,San Diego, California, 1996.
41. Seasholtz TM,Cai G, Wang HY, Friedman E, Johnson MD. Alpha adrenergic stimulated desensitization of vascular phospholipase C activity.Presented at the American Heart Association 67thScientific Sessions, Dallas, Texas,1994.
42. Seasholtz TM,Cai G, Snyder DL, Johnson MD. Ischemia-reperfusion decreases norepinephrine release and enhances alpha adrenergic receptor function at the vascular neuroeffector junction.Presented at the American Heart Association 67thScientific Sessions,Dallas, Texas,1994.
43. Cai G, Bao Y, Jiang Z. Protective effect of ligustrazin on myocardial ischemia-reperfusion injury in rabbits.Presented at the Beijing International Conference on Heart Research, Beijing, China, 1992.

陈隆文 职称:医学博士/生物化学博士 擅长:女性生殖、泌尿、细胞学 单位:美国梅奥医学中心 (Mayo Clinic)亚利桑拿医院 病理科

1992年 毕业于北京医科大学,同年在北京儿童医院任主治医生。1993年 赴美在美国伊利诺斯大学医学院从事前列腺癌的生物化学研究。1999年 获美国伊利诺斯大学 (University of Illinois) 医学院生物化学博士学位。

2000年 通过美国医生资格考试,并被美国的芝加哥大学(University of Chicago) 医院及医学中心接收为病理住院医师,接受系统的解剖病理和临床病理学及检验学的训练。

2003年 获芝加哥大学医院病理系住院总 (Chief Resident)。

2004年 完成住院医师训练并通过美国病理学院解剖病理和临床病理的资格考试。同年, 进入芝加哥大学医院继续深造,从师著名细胞病理权威 Richard Mac DeMay 教授专功细胞病理。

2005年 通过美国病理学院 (American Board of Pathology-Cytopathology) 细胞病理学专科考试并获资格证书。2005-2011美国克里夫兰医学中心 (Cleveland Clinic) 针吸细胞病理学室主任,外科病理学与细胞病理学主任医师

2011年 美国梅奥医学中心(Mayo Clinic) 亚利桑拿医院病理系病理学主任医师及病理高级顾问.

2013年 美国梅奥医学中心(Mayo Clinic) 亚利桑拿医院病理系细胞病理室主任及病理高级顾问

讲座:

陈隆文博士受邀在许多国际会议上作专题讲座,包括在美国加拿大病理学会(United States and Canadian Academy of Pathology)年会上开设“细胞病理学” (2008-2011年)讲座,在美国病理学会(College of American Pathologists)年会上开设“细胞病理学” (2012-2013年)讲座和Video Microscopy,分别在2008年中国病理学年会,2009-2012年中国细胞病理学年会,2010年巴西细胞病理学年会, 2011年欧洲细胞病理年会,2012年在南非举办的国际病理学会大会 (IAP),2013年国际细胞学年会,2013年亚太病理学大会,及2013年巴西病理学年会上做主题演讲。他受邀去多个大学医院做访问教授,包括美国的芝加哥大学,凯斯西部大学, 纽约大学,哈佛大学麻省总医院及加拿大的卡尔加里大学。

樊芳 职称:教授 擅长:宫颈、穿刺细胞学 单位:堪萨斯大学医学中心 病理科

樊芳教授1989年毕业于上海医科大学医学系 (现复旦大学医学院),1995年获得美国堪萨斯大学医学中心药理学博士学位,并从事两年博士后的研究工作。1997年至2002年在堪萨斯大学医学中心病理系完成了解剖病理和临床病理的住院医师的培训和细胞病理的专科培训。现为堪萨斯大学医学中心病理系教授,并任细胞病理科主任和细胞病理专科培训主任。樊芳教授于2012 年获得Barbara F. Atkinson, MD, Endowed Professor of Pathology 的称誉。樊芳教授从事教学和临床工作多年,发表了近70篇文章,主编和参与编写了多本病理学专著,包括一本在美国病理住院医生和细胞病理专科医生中很受欢迎的《Cytopathology Review》和已经第二版的《Cancer Grading Manual》。她在2012年应美国Oakstone 出版社的邀请,组织录制了一整套细胞病理的课程,因为销量和反馈很好,于2015年七月再次受邀,增加和更新了讲课内容,组织录制了第二版共15节课的细胞病理的课程。樊芳教授还多次在美国的多个病理年会上讲课和讨论病例,包括美国的细胞学病理年会,CAP和ASCP的年会。樊芳教授也参加了华夏病理网网络病理学院《宫颈细胞病理学》和《细针穿刺细胞学》 的授课。

主要著作:

Tawfik,O., Fan, F., Damjanov, I.: Atlas of Gynecologic Pathology, McGraw Hill, NewYork, 2006.

Damjanov, I., Fan, F.: Cancer Grading Manual, Springer Verlag, New York-London, 2007.

参与编写的部分书的章节:

Thomas, PA, Fan, F: Aspiration of Breast, in Barbara Atkinson (ed.). (2003) Atlas of Diagnostic Cytopathology (2nd edition). Philadelphia, PA, Saunders.

郭明 职称:副教授 擅长:宫颈、肺 单位:美国德克萨斯州立大学安德森癌症中心 病理科

郭明(Ming Guo)博士,病理学副教授。1982年毕业于北京大学医学部(北京医科大学),1986年获协和医科大学病理学硕士学位。1987至1993年先后在美国达拉斯德克萨斯州立大学西南医学中心细胞生物学系及加拿大金斯顿皇后大学医学系及病理学系从事博士后研究工作。1993年至1996年在加拿大纽芬兰纪念大学医学中心病理学系接受病理解剖学住院医培训;1996至1997年在美国密西西比州立大学医学中心病理学系/细胞病理学部接受细胞病理学专家培训。1996获得美国病理学委员会:美国病理学委员会解剖病理学资格证书;1999年获得美国病理学委员会:美国病理学委员会细胞病理学资格证书。目前具有德克萨斯州及加利福尼亚州医学委员会医师资格证书。



自1997-2004, 郭明博士在美国密西西比州立大学医学中心病理学系/细胞病理学部任病理医师,助理教授。 自2004到现在, 在美国德克萨斯州立大学安德森癌症中心病理学部/细胞病理学部任病理医师,助理教授, 副教授。 郭明博士为美国临床病理及美国细胞病理协会会员。任安德森癌症中心研究经费审核委员会成员。曾获多项研究经费和奖励, 共发表50多篇学术论文。目前从事病理诊断,细胞病理专家培训及临床细胞病理研究工作。主要兴趣为宫颈癌及肺癌早期诊断。

胡清龙 职称:病理医师 擅长:血液病理 单位:亚尼桑那州圣约瑟夫医院 病理科

胡清龙,美国华人病理医生,亚专业血液病理。现为亚尼桑那州图森市圣约瑟夫医院(Carondelet SaintJoseph Hospital, Tucson, Arizona) 病理医师。
他是湖北省天门市人,1978初至1982年底就读于广州市中山医学院医疗系。1983-1989 年先后在湖北省肿瘤医院和北京协和医科大学/中国医科院肿瘤医院从事肿瘤临床工作,师从肿瘤内科孙燕院士。1987年获肿瘤临床免疫硕士学位。出国前相继任中国医科院肿瘤医院内科总住院医生和主治医生。
1989年底前往加拿大多伦多大学安大略癌症研究所从事白血病分子生物学的研究,并于1994年获得年获多伦多大学科学硕士学位。1997年通过美国医学执照考试并获行医执照。 1998年7月-2002年6月在纽约长岛Nassau University Medical Center接受病理住院医生训练。 2002 年通过美国病理医生执照考试并获证书。 随后在休士顿MD Anderson Cancer Center接受血液病理亚专业训练,并获该癌症中心毕业证书。随后通过美国血液病理医生执照考试并获证书。2003年后, 他在加拿大沙省皇家大学医院 (Royal University Hospital)任病理医生兼临床助理教授。 2004年-2009年在Creighton University Medical School/Medical Center 任血液病理医生和助理教授。 2009年,离开学术和教学,专注于病理临床诊断至今。
他在30多年的医学生涯中,在肿瘤临床,科研,和诊断方面积累了比较丰富的经验,在中文和英文杂志上发表医学论文近30篇。他多次在中国组织和主持国际学术会议,多次应邀到国内大学和癌症中心讲学,曾任湖北省肿瘤医院和河南省肿瘤医院访问教授。帮助中国训练病理医生。他是美国华人执业医师协会会员,美国亚尼桑那华人医师协会理事。他热爱工作, 对病人充满责任和爱心,深受同事和病人的肯定和信仼。他是华夏病理网络义务讲师, 并以微信为平台,进行大量义务会诊。
他爱好广泛。阅读历史,人物传记,以及古今中外文学作品。曾任加拿大中国笔会主席,并在国内外报刊杂志上发表散文和诗歌,现已创作诗歌近百首。他热爱生活, 打网球,羽毛球和乒乓球,爱好养花种菜。

孔祥田 职称:病理学家 擅长:泌尿病理 单位:美国加州Kaiser Permanente Sacramento Medical Center 病理科

教育背景及培训经历:1. 1984-1990,北京大学医学部,医学博士;2. 1990-1995,北京大学医学部,病理住院医师;3. 2000-2002,纽约大学医学院皮肤科,从事博士后研究工作;4. 2003-2009,纽约大学医学院病理系,副研究员;

5. 2009-2013,纽约大学医学院病理系,病理专科医师;

6. 2013-2014,纽约Sloan-Kettering纪念癌症中心病理系,肿瘤外科病理医师;

7. 2014-2015,纽约大学Langone医学中心病理系,泌尿病理专科医师。

学术背景:

1. 1995-2000,北京大学医学部泌尿研究所病理研究室,助理教授;

2. 2000.7-2000.8,北京大学医学部泌尿研究所病理研究室,副教授。

资质和认证:

1. 1990年,北京大学医学部,医学博士;

2. 2013年,纽约大学医学院,病理专科医师资格;

3. 2013年,美国病理学委员会,解剖和临床病理资格;

4. 2013-3-14,美国国家医师执照(编号:269195);

5. 2014,纽约Sloan-Kettering纪念癌症中心,肿瘤外科病理医师资格;

6. 2014-2016,纽约州卫生部门颁发行医资格证书;

7. 2015-至今,新墨西哥州卫生部门颁发行医资格证书。

学会任职:

1. 美加病理学会,委员;

2. 国际泌尿病理学会,委员;

3. 美国病理医师学院,委员;

4. 美国华人医师学会,委员;

5. 美国临床病理学会,委员;

6. 美国医学会,委员。

荣誉和奖励:

1. 2010-01,国际泌尿病理学会奖励;

2. 2010-05,美国华人医师学会,三等奖;

3. 2010-11,美国马里兰州巴尔的摩市,国际泌尿病理学会资助从师Dr. Jonathan Epstein博士(约翰霍普金斯医院)专修泌尿专科病理;

4. 2014-03,国际泌尿病理学会优秀泌尿病理专科医师奖。

授课经历:

1. 1995-2000,北京大学医学部讲授病理学;

2. 2009-2013,纽约大学讲授头颈部病理、胸部病理、胃肠病理、血液病理、神经病理等;

3. 2013/10,纽约Sloan-Kettering纪念癌症中心讲授“骨化性肌炎样软组织动脉瘤样骨囊肿”。

其它专业活动:

1. 2008/12,芝加哥大学病理系,受邀发表“前列腺腺癌诊断中冰冻切片分析的应用”演讲;

2. 2011年,“北美医学与科学杂志”的同行评议专家。

发表的论文和专著

1. Huang CC , Kong MX,Zhou M, Rosenkrantz AB, Taneja SS, Melamed J, and Deng FM. Gleason Score 3+4=7 prostate cancer with minimal quantity of gleason pattern 4 on needle biopsy is associated with low-risk tumor in radical prostatectomy specimen.Am J SurgPathol. 2014 May 28. PMID: 24832163

2. Kong MX, Hale C,Subietas-Mayol A, Lee P, Cassai ND, McRae G, Goldfarb DS, Zhou M, Wieczorek R.Bilateral tubulocystic renal cell carcinomas in diabetic end-stage renal disease: first case report with cytogenetic and ultrastructural studies. Rare tumors 2013; 5:185-188 PMID: 24416491

3. Bosland MC, Kato I, Zeleniuch-Jacquotte Anne, Schmoll J, Enk Rueter E, Melamed J, Kong MX, Macias V, Kajdacsy-Balla A, Lumey LH, Xie H, Gao W, Walden P, Lepor H, Taneja SS, Randolph C, Schlicht MJ, Meserve-Watanabe H, Deaton RJ, Davies JA. Effect of Soy Protein Isolate Supplementation on Biochemical Recurrence of Prostate Cancer after Radical Prostatectomy: A Randomized Placebo-Controlled Trial. JAMA 2013;310(2):170-178. PMID: 23839751

4. Deng FM, Zhao Y, Kong X, Lee P, Melamed J. Construction of tissue microarrays using pre-existing slides as source of tissue when paraffin blocks are unavailable. J Clin Pathol. 2013 Mar 9. PMID: 23476078

5. Kong MX, Zhao X, Kheterpal E, Lee P, Taneja S, Melamed J, Deng FM. Histopathologic and clinical features of vesical diverticula. Urology. 2013 Mar 26. pii: S0090-4295(13)00213-6. doi: 10.1016/j.urology.2013.02.015. PMID: 23540860

6. Rosenkrantz AB, Mussi TM, Hindman H, Lim RP, Kong MX, Babb JS, Melamed J, Taneja SS. Prostate Cancer: Impact of Post-Biopsy Hemorrhage and Delay after Biopsy on Tumor Detection using Multi-parametric MRI-A Multi-Reader Study. Clinical Radiology. 2012, 67, e83-e90. PMID: 22981729

7. Liu HG, Kong MX, Yao Q, Wang SY, Martiniuk F, Shibata R, Yee H, Wang BY. Expression of Sox10 and c-kit in Sinonasal Mucosal Melanomas arising in the Chinese population. Head and neck pathology Journal. 2012, 6(4):401-408 PMID: 22736149

8. Kong MX, Newman K, Goldenburg R, Tierno PM, Mikolaenko I, and Rapkiewicz A. Fatal mycoplasma pneumoniae infection: case report and review of the literature. North American Journal of Medicine and Science. 2012 April; 5(2):126-30.

9. Rosenkrantz AB, Mannelli L, Kong X, Niver BE, Berkman DS, MD, Babb JS, Melamed J, and Taneja SS. Prostate Cancer: Utility of Fusion of T2-Weighted and High b-Value Diffusion-Weighted Images for Peripheral Zone Tumor Detection and Localization. Journal of Magnetic Resonance Imaging. 2011; 34:95-100 PMID: 21698707

10. Ye H, Kong X, He TW, Jolis T, Choi K, Lepor H, Melamed J. Intraoperative Frozen Section Analysis of Urethral Margin Biopsies During Radical Prostatectomy. Urology. 2011 May 28; 78(2):399-404 PMID:21624646

11. Rosenkrantz AB, Kong X, Niver BE, et al. Prostate cancer: comparison of tumor visibility on trace diffusion-weighted images and the apparent diffusion coefficient map. AJR Am J Roentgenol. 2011 Jan; 196(1):123-9. PMID: 21178056

12. Rosenkrantz AB, Kopec M, Kong X, Melamed J, Dakwar G, Babb J, Taouli B. Prostate Cancer versus Post-Biopsy Hemorrhage: Diagnosis with T2- and Diffusion-Weighted Imaging. Journal of Magnetic Resonance Imaging. 2010; 31:1387-1394. PMID: 20512891

13. Rosenkrantz AB, Neil J, Kong X, et al. Prostate Cancer: Comparison of 3D T2-Weighted With Conventional 2D T2-Weighted Imaging for Image Quality and Tumor Detection. AJR Am J Roentgenol. 2010 Feb; 194(2):446-52. PMID: 20093608

14. Xu K, Shimelis H, Linn DE, Jiang R, Yang X, Sun F, Guo Z, Chen H, Li W, Chen H, Kong X, Melamed J, Fang S, Xiao Z, Veenstra TD, Qiu Y. Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. Cancer Cell. 2009 Apr 7; 15(4):270-82. PMID: 19345326

15. Guo Z, Yang X, Sun F, Jiang R, Linn DE, Chen H, Chen H, Kong X, Melamed J, Tepper CG, Kung HJ, Brodie AM, Edwards J, Qiu Y. A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgendepletion-resistant growth. Cancer Res. 2009, 69:2305-13. PMID: 19244107

16. Peng Y, Chen F, Melamed J, Chiriboga L, Wei J, Kong X, McLeod M, Li Y, Li CX, Feng A, Garabedian MJ, Wang Z, Roeder RG, Lee P. Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer. Proc Natl Acad Sci U S A. 2008; 105:5236-5241. PMID: 18356297

17. You Z, Dong Y, Kong X, Beckett LA, Gandour-Edwards R and Melamed J. Midkine is a NF-κB-inducible gene that supports prostate cancer cell survival. BMC Medical Genomics 2008, 1:6-16.PMID: 18275606

18. You Z, Dong Y, Kong X, Zhang Y, Vessella RL and Melamed J. Differential expression of IL-17RC isoforms in androgen-dependent and androgen-independent prostate cancers. Neoplasia 2007; 9:464-470. PMID: 17603628

19. Kong X, Zhao Y, Ksionsk M, Zhou M, Walden P, Bosland MC, Pei Z, Lee P, Melamed J. Radiographic determination of tissue thickness in paraffin blocks: Application to the construction of tissue microarrays. Applied Immunohistochemistry & Molecular Morphology, 2007; 15:108-112. PMID: 17536317

20. Kajdacsy-Balla A, Geynisman JM, Macias V, Setty S, Nanaji NM, Berman JJ, Dobbin K, Melamed J, Kong X, Bosland M, Orenstein J, Bayerl J, Becich MJ, Dhir R, Datta MW; The Cooperative Prostate Cancer Tissue Resource. Practical aspects of planning, building, and interpreting tissue microarrays: The Cooperative Prostate Cancer Tissue Resource experience. J Mol Histol. 2007 May;38(2):113-21. PMID: 17318343

21. Guo Z, Dai B, Jiang T, Xu K, Xie Y, Kim O, Nesheiwat I, Kong X, Melamed J, Handratta VD, Njar VCO, Brodie AMH, Yu LR, Veenstra TD, Chen H, and Qiu Y. Regulation of Androgen Receptor by Tyrosine Phosphorylation. Cancer Cell 2006;10:309-319. PMID: 17045208

22. Dai B, Kim O, Xie Y, Guo Z, Xu K, Kong X, Melamed J, Chen H, Bieberich CJ, Borowsky AD, Kung HJ, Wei G, Ostrowski MC, Brodie A, and Qiu, Y. Tyrosine Kinase Etk/Bmx Is Upregulated in Human Prostate Cancer and Its Overexpression Induces Prostate Intraepithelial Neoplasia in Mouse. Cancer Research 2006; 66: 8058-8064. PMID: 16912182

23. Kong XT, Deng FM, Hu P, Liang FX, Zhou G, Auerbach AB, Genieser N, Nelson PK, Robbins ES, Shapiro E, Kachar B, and Sun TT. Roles of uroplakins in plaque formation, umbrella cell enlargement, and urinary tract diseases. Journal of Cell Biology 2004;167:1195-1204. PMID: 15611339

24. Li S, Kong X,Shan G. Ultrasonographic manifestations and histological structures of prostate adenocarcinoma. Chinese Journal of Ultrasound Medicine 2001 March,17(3):334-336.

25. Zeng L, Kong XT,Su JW, Xia TL, Na YQ, Guo YL. Evaluation of germ-cell kinetics in infertilepatients with proliferating cell nuclear antigen proliferating index. Asian J Androl 2001 March;3(1):63-66. PMID: 11250796

26. Kong X, Zeng L,Mi P. Carcinoma of kidney collecting duct: an analysis of 10 cases. Zhonghua Zhong Liu Za Zhi 2001 March;23(2):162-164. PMID: 11783026

27. Kong X, Zeng L,Mi P, et al. The clinical and pathological manifestations of papillary renal cell carcinoma. Chin J Urol 2001Jan; 22(1):77-80.

28.Kong X, Zeng L, Xia T, et al. Evolution of stromal nodules in benign prostatic hyperplasia. Journal of Beijing Medical University 2000;32(4):378-380.

29. Kong X, Zeng L, Yang Y, Xia T, Gu FL, Guo YL,and Lee C. Immunohistochemical characterization of stromal nodules in benign prostatic hyperplasia. The Prostate Journal 2000;2(4):199-204.

30.Kong X, Xi Z, Mi P, et al. Correlation between expression of urothelial differentiation-associated uroplakin and differentiation of bladder transitional cell carcinoma. Chinese Journal of Urology 2000;21:134-136.

31. Wang S, Xia T, Zhang Z, Kong X, Zeng L, Mi P, Xue Z. Expression of VEGF and tumor angiogenesis in bladder cancer. Zhonghua Wai Ke Za Zhi. 2000 Jan;38(1):34-6. PMID: 11831983

32. Kong X, Tu P, Li J, et al. The value of Ca15-3 in differential diagnosis of Paget’s disease. Journal of Beijing Medical University 1999;31:426-428.

33. Kong X, Zeng L, Xia T, Wang J, Mi P, Na Y, Xue Z, Pan B, Hao J, Gu FL, Guo YL. The effect of combined endocrine therapy on prostate and testis. Zhonghua Wai Ke Za Zhi 1999 April;37(4):231-234. PMID: 11829828

34. Kong X, Li J, Xue Z, Zeng L, Shen L, Xia T, Gu F, and Guo Y. Clinicopathologic study of 11 patients with Paget's disease of scrotum. Zhonghua Wai Ke Za Zhi. 1999 Jul;37(7):424-6. PMID: 11829879

35. Zeng L, Xia T, Kong X, Gu F. Massive lipoma of the scrotum. Chin Med J(English). 1999 Jan;112(1):84-5. PMID: 11593649

36. Jiang XJ, Feng T, Chang LS, Kong XT, Wang G, Zhang ZW, Guo YL. Expression of osteopontin mRNA in normal and stone-forming rat kidney. Urol Res 1998;26:389-94.

37. Kong X, Xia T, Zeng L. A study of fat content and its local distribution in misdiagnosed renal angiomyolipoma. Chinese Journal of Urology 1998;19:658-659.

38. Jin J, Guo B, Kong X. Multilocular cyst of kidney. Zhonghua Wai Ke Za Zhi. 1998;36:57-8.

39. Li H, Yu L, Yang B, Kong X, Mi P, Guo Y. Expression and significance of Fas/APO-1 and bcl-2 protein in renal cell carcinoma. Zhonghua Wai Ke Za Zhi. 1998 Jul;36(7):409-11. PMID:11825426

40. Yang B, Gu F, Li H, Kong X, Yu L. Apoptosis of renal cell carcinoma and apoptotic related genes bcl-2 and bax. Zhonghua Wai Ke Za Zhi. 1998 Jun;36(6):373-5. PMID: 11825416

41. Pan B, Song Y, Kong X, Xue Z, Guo Y. Primary epididymal tumors. Zhonghua Wai Ke Za Zhi. 1998 Mar;36(3):138-40 PMID: 11825350

42. Ding Y, Kong X, Yu L, et al. Reversion of drug resistance in intrinsic drug resistance cell line GRC-1. Chinese Journal of Urology 1997, 18:651-653.

43. Kong X, Xia T and Gu F. Study of the latent carcinoma of Prostate in China. Br J Urol 1997 Sept;80(suppl 2):229.

44. Kong X, Ding Y, Xia T. Drug resistance and its mechanism of intrinsic drug-resistant cell line GRC-1. Zhonghua Wai Ke Za Zhi 1997 Nov;35(11):697-9. PMID: 10678018

45. Zhong H, Deng F, Kong X. Expression of basic fibroblast growth factor and its receptor in renal cell carcinoma. Zhonghua Wai Ke Za Zhi 1996 Nov;34(11):651-4. PMID: 9590749

46. Kong X, Xia T, Mi P. The diagnosis of prostatic cancer by transrectal fine needle aspiration. Chinese Journal of Pathology 1996;25:244-245.

47. Kong X, Xia T, Gu F. Expression of mdr1 messenger RNA in human renal cell carcinomas. Chinese Journal of Urology 1996;17:330-332.

48. Kong X, Deng F, Wang J. The application of high molecular weight cytokeratin in differential diagnosis of prostate adenocarcinoma. Zhonghua Bing Li Xue Za Zhi 1996 Aug;25(4):199-201. PMID:9275650

49. Kong X, Xia T, Gu F. Expression of mdr-1 gene product in primary renal cell carcinoma and its clinical significance. Chinese Journal of Urology 1995;16:329-331.

50. Gu FL, Xia TL, Kong XT. Preliminary study of the frequency of benign prostatic hyperplasia and prostatic cancer in China. Urology 1994 Nov;44(5):688-91. PMID: 7526525

51. Kong X, Zou WZ, Wang CS. Comparison of kidney structure in young with old mice and the effect of kidney nourishing recipes on the glomerular basement membrane. Chinese Journal of Geriatric Medicine 1994, 13:53-55.

52. Xia T, Kong X, Su J. Pathogenesis and histopathology of benign prostate hyperplasia in adult Chinese. Chinese Journal of Urology 1993, 14:415-417.

53. Kong X, Xia T, Ma W. The clinicopathological features of testis tumors. Chinese Journal of Urology 1993, 14:375-8. Books, Chapters

54. Kong, X. (1996). Pathology of prostate. In Modern Prostate Disease. By Gu, X. and Pan, B. (Beijing Medical University Press, Beijing, China, ISBN 7-81034-551-6), pp52-138.

55. Kong, X. and Guo, Y. (1998). The pathologic diagnosis of prostatic cancer. In Benign Prostate Hyperplasia and Prostate Cancer. By Guo, Y. (The People’s Public Health Press, Beijing, China,ISBN 7-117-03020-8), pp194-202.

56. Kong, X. and Xia,T. (2000). Fine needle aspiration of prostate, kidney, and adrenal gland. In Diagnostic Cytopathology. By Ma, Z., Kan, X., and Liu, S. (Henan Science and Technical Publishing House, Zhengzhou, China, ISBN 7-5349-2030-2), pp615-627.

57. Kong, X. and Xia, T. (2002). Testis tumor. In Contemporary Urologic Pathology. By Xia, T. (The People’s Public Health Press, Beijing, China, ISBN 7-117-04979-0), pp360-393.

58. Sun, T.T., Kong, X., Deng, F.M., and Liang, F.X. (2002). Uroplakins and the diseases of urinary tract. In Modern Prostate Disease. By Xia, T. (The People’s Public Health Press, Beijing, China, ISBN 7-117-04979-0), pp751-760.

Abstracts

1. Kong M, Brannon AR, Won H, Gandhi A, Al-Ahmadie HA, Fine SW, Gopalan A, Russo P, Berger MF, Tickoo SK, Ying-Bei Chen YB. mTOR Pathway Activation Characterizes a Subset of Unclassified Renal Cell Carcinoma: Immunohistochemical, Molecular and Histologic Analysis. The 103rd USCAP annual meeting, San Diego, California, USA. Mar. 1-7, 2014.

2. Kong M, Drill E, Klimstra D, Ghossein R, Gonen M and Katabi N. Proliferative grading predicts outcome in myoepithelial Carcinoma of Salivary Glands: A Clinicopathologic Study of 48 cases. The 103rd USCAP annual meeting, San Diego, California, USA. Mar. 1-7, 2014.

3. Huang CC, Kong M, Ren Q, Deng FM, Melamed J, Zhou M. Prostate cancer multifocality and heterogeneity: Implications for Gleason grading, tumor volume measurement and tissue sampling for research. The 102nd USCAP annual meeting, Baltimore, Maryland, USA. Mar. 2-8, 2013.

4. Ren Q, Kong MX, Wu X, Deng FM, Melamed J, Monaco ME, Lee P. Role of Long-chain fatty Acyl-CoA synthetase 4(ACSL4) in prostate cancer progression. The 102nd USCAP annual meeting, Baltimore, Maryland, USA. Mar. 2-8, 2013.

5. Kong MX, Ren Q, Wang B, Cangiarella J and Sun W. The occurrence of papillary thyroid carcinoma in patients undergoing thyroidectomy for Hurthle cell adenoma: a comparative study. XXIX Congress of the International Academy of Pathology 2012, Cape Town, South Africa, 09/29-10/05/2012.

6. Kong MX, Ligr M, Sarpel U, Lee L, Ren Q, Cho M, Hadju C, Konno F, Taboada S, Lee P and Xu R. Over-expression of TIF1gamma is a common event in hepatocellular carcinoma irrespective of viral etiology and neoadjuvant therapy. XXIX Congress of the International Academy of Pathology 2012, Cape Town, South Africa, 09/29-10/05/2012.

7. Kong MX, Zhao X, Kheterpal E, Lee P, Taneja S, Melamed J and Deng FM. Histopathologic and Clinical Features of Vesical Diverticula. USCAP 2012,Vancouver, Canada, Mar. 17-23, 2012.

8. Hale C, Kong MX, Ren Q, et al. Decreased Stromal Androgen Receptor Expression in African-Americans with Prostate Cancer. USCAP 2012, Vancouver, Canada, Mar. 17-23, 2012.

9. Kong MX, Ren Q, Deng FM, Rosenkrantz A, Taneja S, Melamed J, Mendrinos S. Unilateral adenocarcinoma and high grade prostatic intraepithelial neoplasia in prostatectomies. Possible implication for patient care. ASCP 2011 annual meeting/WASPaLM XXVI world congress, Las Vegas, Oct. 19-22, 2011.

10. Kong MX, Hale C, Subietas-Mayol A, Cassai ND, McRae G, Goldfarb DS, Zhou M, Wieczorek R. Bilateral tubulocystic renal cell carcinomas associated with acquired end-stage renal disease: The first case report with cytogenetic and ultrastructural studies. ASCP 2011 annual meeting/WASPaLM XXVI world congress, Las Vegas, Oct. 19-22, 2011.

11. Konno F, Kong X, Wang J, Hajdu CH and Xu R. Predictive value of histological findings in postperfusion liver biopsy for onset of rejection and hepatitis C recurrence in liver allografts. CAP’11 The pathologists’ meeting/Gaylord Texan, Sept. 11-14,2011. Grapevine (Dellas), Texas, USA. Arch pathol Lab Med, 135, September 2011, pp1119.

12. Taboada S, Hajdu C, Lee L, Kong X and Xu R. Differences in Alcian Blue/Periodic Acid-Schiff staining are associated with differences in expression of immunohistochemical markers, Transcriptional Intermediary Factor 1γ and CD44 in diffuse-type gastric adenocarcinoma. CAP’11 The pathologists’ meeting/Gaylord Texan, Sept. 11-14, 2011. Grapevine (Dellas), Texas, USA. Arch pathol Lab Med, 135, September 2011, pp1117.

13. Sun W, Kong MX, Xu RL, Yee M, Roses D, Han E, Wang B. Over expression of TIF-1 in papillary thyroid carcinoma. Proceedings of Taiwan Society of Pathology. Asia Pacific IAP Congress. PP155, May 20-24, 2011, Taiwan.

14. Liu HG, Yao Q, Wang SY, Kong MX, Ho H, Sun W, Wang BY, Immunohistochemical expression of Sox10 in mucosal melanomas of the head and neck. Proceedings of Taiwan Society of Pathology. Asia Pacific IAP Congress. PP90, May 20-24, 2011, Taiwan.

15. Deng FM, Zhao Y, Kong X, Lee P, Melamed J. Patch TMA Construction Using Pre-Existing Slides as Source of Tissue When Paraffin Blocks Are Unavailable. Poster presentation #1910, USCAP 100th Annual meeting, San Antonio, Texas, Feb.26-Mar. 4, 2011.

16. Ding Y, Kong X and Xu R. Esophageal xanthoma: report of one case and review of the literature. The 15th Annual convention & Gala, Association of Chinese American physicians, USA (ACAP), New York, 2010

17. Neil J, Rosenkrantz A, Kong X, Melamed J, Taneja S, Taouli B. Volumetric 3D T2-weighted sequence of the prostate (SPACE): comparison with conventional 2D T2 for image quality and tumor detection. Proceedings of the 17th Annual Meeting of the ISMRM, Honolulu, 2009 (4258).

18. Rosenkrantz A, Kopec M, Kong X, Melamed J, Taneja S, Lepor H, Taouli B. Utility of Quantitative T2 Signal Intensity and ADC Measurements in Differentiating Prostate Cancer From Post-Biopsy Hemorrhage. Proceedings of the 17th Annual Meeting of the ISMRM, Honolulu, 2009 (2242).

19. Kong X, Ye H, Cetin N, Small J, Lee P, Melamed J. (2008, March). A Systematic Evaluation of Histopathologic Criteria for Adenocarcinoma of Prostate Using Frozen Sections as Compared with Routine Permanent Sections. Poster presented at: USCAP;Denver, Colorado.

20. Ye H, Kong X, Lee P, Melamed J. (2008, March). Intraoperative Frozen Section Analysis of Apical Margin Biopsies during Radical Prostatectomy: Ten Year Experience from a Single Institution. Platform presented at: USCAP; Denver, Colorado.

21. Basturk O, Wei J, Kong X, Zou X, Peng Y, Melamed J, Lee P. (2008, March). MicroRNA Expression in Androgen Independent and Metastatic Prostate Cancer. Poster presented at: USCAP; Denver, Colorado.

22. Lin L, Melamed J, Kong X, Chiriboga L, Yee H, Zhang X, Wei JJ, Ligr M, Peng Y, Basch R, Lee P. (2008, March). Characterization of Nuclear Hormone Receptor Cofactor TBLR1 Expression in Adenocarcinoma of the Prostate. Poster presented at: USCAP;Denver, Colorado.

23. Peng L, Melamed J, Kong XT, ZhaoY, KsionskM, Peng Y, Lee P, Wei JJ. (2007, March). Overexpression of MicroRNA let-7c in Prostate Cancer. Poster presented at: USCAP; San Diego, CA.

24. Zhao Y, Kong X, Ksionsk M, Lee P, Bannan MB, Melamed J. (2007, March). Patch Tissue Microarray (TMA): A Novel Technique for TMA Construction Using Pre-Existing Slides as a Source of Tissue When Paraffin Blocks Are Unavailable. Poster presented at:USCAP 2007; San Diego, CA.

25. Zhao Y, Kong X, Ksionsk M, et al. An accurate method for determination of tissue thickness in paraffin blocks by Faxitron analysis: Application to tissue microarray construction.USCAP, San Antonio, Texas, Mar. 2005. Modern Pathology 18:supplement 337A, 2005

26. Zhang XM, Chiu J, Kong XT, et al. Upregulated expression of androgen receptor (AR) specific transcription corepressors in prostate cancer. USCAP, San Antonio, Texas, Mar. 2005. Modern Pathology 18:supplement 174A, 2005

27. Guo CC, Kong X, Lee P, Melamed J. Expression of mucin antigens in renal tumors. USCAP, San Antonio, Texas, Mar. 2005. Modern Pathology 18:supplement 143A, 2005

28. Kong XT, Xia TL, and Gu FL. Study of the latent carcinoma of prostate in China. SIU Montreal 1997 - Societe Internationale d’Urologie 24th World Congress, Montreal, Quebec, Canada, Sept.7-11, 1997

29. Ding Y, Yu L, Kong X, et al. Study of reverse-drug resistance and its mechanism in intrinsic drug-resistant cell line GRC-1. SIU Montreal 1997 - Societe Internationale d’Urologie 24th World Congress, Montreal, Quebec, Canada, Sept.7-11, 1997

30. Kong X, Gu FL, Xia T, et al. Expression of MDR-1 gene and its product P-glycoprotein in kidney cancer. The Third Beijing International Symposium on Recent Advances in Urology (BISU’95) Beijing, China, Oct.11-14, 1995

31. Kong X, Ding Y, et al. Intrinsic multidrug resistance in human kidney cancer cell line GRC-1. The Third Beijing International Symposium on Recent Advances in Urology (BISU’95) Beijing, China, Oct.11-14, 1995

32. Kong X, Xia TL, Gu FL, et al. Latent carcinoma of prostate in China. The Third Beijing International Symposium on Recent Advances in Urology (BISU’95) Beijing, China, Oct.11-14, 1995

潘增刚 职称:MD / PHD 擅长:血液病理 单位:美国科罗拉多大学 病理科

潘增刚, MD,PhD,现在职称:助理教授,病理学。专业方向:血液病理学,普通外科病理学。现在单位:科罗拉多大学医学中心病理学系,美国科罗拉多州,联系地址: Department of Pathology
University of Colorado Anschutz Medical Campus
12605 East 16th Avenue,Mailstop F768
Aurora, CO 80045
联系电话:(Office) 720-848-7052
电子邮箱:zenggang.pan@ucdenver.edu
个人网站:www.enjoypath.com
资格考试:
· 美国血液病理学资格考试 (2012年9月通过)
· 美国解剖病理学和临床病理学考试 (2010年8月通过)
· 中国医师执业资格考试 (1999年11月通过)
学习和工作经历:
· 2012 -现在:美国科罗拉多大学医学中心,助理教授
· 2011-2012:美国加州City of Hope医学中心,血液病理学专科培训
· 2010-2011:Alabama大学病理学系,外科病理学专科培训
· 2006-2010:美国Creighton大学医学中心,解剖病理和临床病理,住院医培训
· 2000-2006:美国Nebraska大学医学中心和淋巴瘤研究中心,病理学博士
· 1997-2000:北京医科大学病理学系,助教、病理住院医和淋巴瘤研究
· 1996-1997:北京医科大学病理学系,淋巴瘤实验室,本科毕业课题设计
· 1992-1997:北京医科大学,医学本科
病理学博士研究生期间的主要工作:在血液病理学家Wing C. (John) Chan 的指导下,从生发中心B细胞以及相关淋巴瘤中克隆了两个新的基因,GCET1和 GCTE2, 现已应用于淋巴瘤的分类和研究中。

PUBLICATIONS
PEER REVIEWED RESEARCH/REVIEW ARTICLES PUBLISHED
· Zenggang Pan, Shimin Hu, Min Li, Yi Zhou, Young S. Kim, Vishnu Reddy, Zifen Gao, Huan-You Wang, Ji Yuan. ALK-positive diffuse large B-cell lymphoma: A clinicopathologic study of 26 cases with review of additional 108 cases in the literature. American Journal of Surgical Pathology. 2017 January;41(1):25-38 (Research Article)
· Liqun Yin, Jie Xu, Min Li, Vishnu Reddy, Quan Zhou, Huanxin Liu, Peiguo Chu, Qianyun Zhang, Qin Huang, Zifen Gao, Huanyou Wang, Xiayuan Liang, and Zenggang Pan. Bob1 and Oct2 Expression in Lineage Determination of B-Cell Lymphomas Negative for Conventional B-Cell Markers. Histopathology. 2016 November;69(5):775-783 (Corresponding Author)
· Bradley M. Haverkos , Zenggang Pan, Alejandro A. Gru, Aharon G. Freud, Rachel Rabinovitch, Meng Welliver, Brad Otto, Carlos Barrionuevo, Robert A. Baiocchi, Rosemary Rochford , and Pierluigi Porcu Extranodal NK/T-cell lymphoma (ENKTL): an update on epidemiology, clinical presentation, and natural history in North American and European cases. Current Hematologic Malignancy Reports. 2016 December;11(6):514-527 (Review Article)
· Zenggang Pan, Jiehao Zhou. IgG4-related lymphadenopathy: a potentially under- and over-diagnosed entity. International Journal of Clinical and Experimental Pathology (Review Article. Accepted, 06/20/16) (Corresponding Author)
· Poomy Pandey, Satyanarayana Rachagani, Srustidhar Das, Parthasarathy Seshacharyulu, Yuri Sheinin, Naava Naslavsky, Zenggang Pan, Brittney L. Smith, Haley L. Peters, Prakash Radhakrishnan, Nicole R. McKenna, Sai Srinivas Panapakkam Giridharan, Dhanya Haridas, Sukhwinder Kaur, Michael A. Hollingsworth, Richard G. MacDonald, Jane L. Meza, Steve Caplan, Surinder K. Batra, and Joyce C. Solheim. Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis. Oncotarget. 2015 Feb 10;6(4):2064-2075.
· Zenggang Pan, Yuanyuan Chen, Xiaojun Wu, Vijay Trisal, Sharon Wilczynski, Peiguo Chu, Huiqing Wu. Merkel Cell Carcinoma of Lymph Node with Unknown Primary Has a Significant Lower Association with Merkel Cell Polyomavirus Than Its Cutaneous Counterpart. Modern Pathology 2014 Sep;27(9):1182-1192
· Zenggang Pan, Qingmei Xie, Susan Repertinger, Bill G. Richendollar, Wing C. Chan, and Qin Huang. Plasmablastic Lymphomas Directly Transformed from Chronic Lymphocytic Leukemia with Newly Acquired C-Myc Gene Rearrangement. Human Pathology. 2013 October;44(10):2139-2148.
· Zenggang Pan, William Grizzle, and Omar Hameed. Immunohistochemical Expression of Renal Markers in Matched Primary and Metastatic Renal Cell Carcinomas. American Journal of Clinical Pathology. 2013 September;140(3):410-418.
· Zenggang Pan, Qianyun Zhang, Zhengbin Lu, Tobi Quinto, Igor B. Rozenvald, Lanting Liu, David Wilson, Vishnu Reddy, Huanyou Wang, Yongsheng Ren. Extracavitary KSHV-Associated Large B-Cell Lymphoma: A Distinct Entity or a Subtype of Primary Effusion Lymphoma? Study of 9 Cases and Review of Additional 43 Cases. American Journal of Surgical Pathology. 2012 August;36(8):1129-1140.
· Haley L. Peters, Amit Tuli, Xiaojian Wang, Cuiling Liu, Zenggang Pan, Michel M, Ouellette, Michael A. Hollingsworth, Richard G. MacDonald, and Joyce C. Solheim. Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells. International Journal of Oncology. 2012 October;41(4):1464-1474
· Zenggang Pan, Yulei Shen, Baosheng Ge, Cheng Du, Timothy McKeithan, Wing C. Chan. Studies of a Germinal Center B-cell Expressed Gene, GCET2, Suggest its Role as a Membrane Associated Adapter Protein. British Journal of Hematology. 2007 June; 137(6):578-590.
· Christine P. Hans, Dennis D. Weisenburger, Timothy C. Greiner, Wing C. Chan, Patricia Aoun, Gregory T. Cochran, Zenggang Pan, Lynette M. Smith, James C. Lynch, Robert Gregory Bociek, Philip J. Bierman, Julie M. Vose and James O. Armitage. Expression of PKC-beta or Cyclin D2 Predicts for Inferior Survival in Diffuse Large B-Cell Lymphoma. Modern Pathology. 2005 October; 18(10):1377-1384.
· Christine P. Hans, Dennis D. Weisenburger, Timothy C. Greiner, Randy D. Gascoyne, Jan Delabie, German Ott, H. Konrad Müller-Hermelink, Elias Campo, Rita M. Braziel, Elaine S. Jaffe, Zenggang Pan, Pedro Farinha, Lynette M. Smith, Brunangelo Falini, Alison H. Banham, Andreas Rosenwald, Louis M. Staudt, Joseph M. Connors, James O. Armitage, and Wing C. Chan. Confirmation of the Molecular Classification of Diffuse Large B-Cell Lymphoma by Immunohistochemistry Using a Tissue Microarray. Blood. 2004 January 1; 103(1):275-282.
· Zenggang Pan, Yulei Shen, Cheng Du, Guimei Zhou, Andreas Rosenwald, Louis M. Staudt, Timothy C. Greiner, Timothy W. McKeithan and Wing C. Chan. Two Newly Characterized Germinal Center B-Cell Associated Genes, GCET1 and GCET2, Have Differential Expression in Normal and Neoplastic B-cells. The American Journal of Pathology. 2003 July; 163(1):135-144.
· Zifen Gao, Fen Jiang, Zenggang Pan. P53 Gene Mutation and EBV Associated Nasopharyngeal T-Cell Lymphoma. The Chinese Journal of Clinical Oncology. 1999 November; 26(6); 429-432.
· Zifen Gao, Faith Ho, Zenggang Pan. Comparative Studies of Nasopharyngeal B-Cell Lymphomas in Hong Kong and Beijing. Journal of Beijing Medical University. 1999 February; 31(2):42-44.
· Zifen Gao, Honghai Wang, Zenggang Pan. Investigation of the Clinicopathologic Features, Immunophenotype and Epstein - Barr virus Infection of the Upper Respiratory Tract Lymphomas. The Chinese Journal of Pathology. 1998 August; 27(4):251-254.

PEER REVIEWED CASE STUDIES PUBLISHED
· Zohra Nooruddin, Nicholas Miltgen, Qi Wei, Jeffrey Schowinsky, Zengang Pan, Jennifer Tobin, Enkhtsetseg Purev, Jonathan A. Gutman, William Robinson, Daniel A. Pollyea. Changes in Allele Frequencies of CSF3R and SETBP1 Mutations and Evidence of Clonal Evolution in a Chronic Neutrophilic Leukemia Patient Treated with Ruxolitinib. Haematologica (Accepted)
· Virginia M. Knez, Zenggang Pan, Qin Chang, Daniel Pollyea, Miriam D. Post, David P. Wang, John W. Ryder, Billie J. Carstens, Karen L. Swisshelm, Xiayuan Liang. A Rare Entity, iAMP21 -Positive B -Lymphoblastic Leukemia in Pregnancy and Literature Review Comparing B-ALL in Pregnancy with the General Population. American Journal of Clinical Pathology Case Reports, 2016, HP16-6.
· Sanjana Mehrotra, Zenggang Pan. Fine needle aspiration cytology of histiocytic sarcoma with dendritic cell differentiation: A case of transdifferentiation from low-grade follicular lymphoma. Diagnostic Cytopathology 2015 Aug;43(8):659-663. (Faculty mentor)
· Kathryn D. Matney, Lynne Meltesen, Karen Swisshelm, Zenggang Pan. Novel Report of a Clonal Myeloproliferative Disorder with Prominent Histiocytic Differentiation. Ann Clin Pathol 2014; 2(5): 1034. (Faculty mentor)
· Zenggang Pan, Warren G. Sanger, Julia A. Bridge, William J. Hunter, Gene P. Siegal and Shi Wei. A Novel t(6;13)(q15;q34) in a Giant Cell Reparative Granuloma. Human Pathology. 2012 June;43(6):952-957.
· Shi Wei*, Zenggang Pan*, Gene P. Siegal, Thomas S. Winokur, Andrew J. Carroll, Darshana Jhala Complex analysis of a recurrent pleomorphic hyalinizing angiectatic tumor of soft parts. Human Pathology. 2012 January ;43(1):121-126. (*Equal contribution)
· Zenggang Pan, Kirby I. Bland, Shi Wei. Composite Cutaneous Langerhans Cell Histiocytosis and Atypical Vascular Lesion After Radiation for Breast Carcinoma: Can Radiation Induce Langerhans Cell Histiocytosis? Dermatology Online Journal. 2011 December; 15;17(12):6
· Zenggang Pan, Susan Repertinger, Ronald Leonard, Chhanda Bewtra, Zoran Gatalica, Poonam Sharma. Cervical and Endometrial Metastases of Appendiceal Goblet Cell Carcinoid. Archives of Pathology & Laboratory Medicine. 2010 May; 134(5): 776-780
· Zenggang Pan, Sanjeev Sharma, Poonam Sharma. Primary Langerhans Cell Histiocytosis of the Vulva: A Rare Disease in an Unusual Location. Indian Journal of Pathology and Microbiology. 2009 January; 52 (1): 65-68.
· Peyman Borghei, Zenggang Pan, Lincoln Berland. Peritumoral Steatosis in Metastatic "Non-functioning" Neuroendocrine Tumor of the Pancreas. Clinical Radiology.
· Zenggang Pan, Susan Repertinger, Caishu Deng, Poonam Sharma. A Giant Cystic Pheochromocytoma from the Adrenal Gland. Endocrine Pathology. 2008 Summer; 19(2):133-138.
· Zenggang Pan, Daniel Albertson, Amardip Bhuller, Bo Wang, James M. Shehan, and Deba P. Sarma. An Angiosarcoma of the Scalp Mimicking a Sebaceous Cyst. Dermatology Online Journal. 2008; 14 (6): 13.
· Zenggang Pan, Bo Wang. Anaplastic Carcinoma of the Pancreas Associated with a Mucinous Cystic Adenocarcinoma: A Case Report and Review of the Literature. Journal of the Pancreas. 2007; 8(6)
· Shuping Shi, Zifen Gao, Zenggang Pan. Multifocal Cutaneous Angiocentric Lymphoma. Chinese Journal of Pathology. 1997 March; 26(3); 164.

王丽娜 职称:病理主治医生 擅长:乳腺、肺、泌尿 单位:美国加利福尼亚州洛杉机南加州大学病理系 病理科

王丽娜, M.D. M.S.美国加利福尼亚州洛杉机南加州大学病理系病理资深主治医生, 助理教授,主要从事外科病理工作。现任南加州大学病理系乳房病理和泌尿外科病理专家。除专长外科病理诊断之外, 还从事医学生和住院医师教学工作。

现主要科研方向为乳腺癌、 肺癌、泌尿外科肿瘤病理的研究。对软组织肿瘤、肾肿瘤和血液病分子遗传病理学感兴趣。

Research Grants

Current

1. V-foundation grant (Oct 31, 2013-Oct 30-2016) PI: Ite Laird_ Offringa (a 3-year grant aimed at developing immunotherapy for SCLC).

SPECIFIC AIMS

The project has three specific aims:

Aim 1. To develop an immunization protocol for mice using native or isoaspartylated HuD.

Aim 2a. To modify the existing SCLC mouse model to accurately mimic human SCLC response to

cisplatin/etoposide (C/E) treatment, remission and ultimately cancer recurrence.

2b. To use this model to test the therapeutic efficacy of anti-HuD immunization.

Aim 3. To determine the optimal time to treat human SCLC patients with immunotherapy by assessing the

immune status of 10 patients prior to C/E treatment and at 3 weeks and 6 weeks after their final cycle.

Role: Co-PI

$600,000

Completed

1. Gingiva Derived MSCs: Role in Immunomodulation and Tissue Regeneration, R01 DE019932, NIH, PI: Anh Le, 2009-2014

Role: Consultant $3,000,459

2 HIV infection of cervical epithelia exposed to alcohol, Alcohol grant (AA-03-0004) ), PI: Anh Le, 2003-2005

Role: Consultant $1,250,000

3. Epidemiology, genetic and molecular biology studies of keloids (1 P01 AR051950-01) (multi-PI), PI: Anh Le, 2004-2005

Role: Consultant $1,000,000

4. Rice Brand Extract Enhances Yeast-Induced Cancer Apoptosis. Grant No. 1AO1CA109048-01, PI : Mamdooh Ghoneum, 2006-2008

Role: Consultant $961,875

over 3 years

5. HPV and Susceptibility Biomarkers in Oral Pre-Cancer, R03 CA 128099-01, NCI, PI: Anh Le, 2007-2009

Role: Consultant $163,000

1978-1983 青岛医学院,医学学士 (本科)

1983-1987 青岛医学院药理系助教

1987-1990 青岛医学院免疫/药理学, 硕士

1990-1996 加州大学洛杉矶分校内科和儿科免疫学助理研究员

1996-2000 Harbor-UCLA Medical Center, 临床和外科病理系住院医生和住院总 (Chief Resident)

2000年通过美国国家病理医生认证资格考试(America Board Certified in AP, CP)

2000-2001 南加州大学外科病理研究员

2001-2002 南加州大学细胞学病理研究员

2002通过美国国家病理医生认证资格考试(America Board Certified in Cytopathology)

2002-2005 King-Drew医学中心细针穿刺和免疫实验室主任

2001-2004 Impath病理顾问

2007-2010 genzyme病理高级顾问

2013 Philips病理高级顾问

2005年至今:美国加利福尼亚州洛杉机南加州大学病理系助理教授

2001年获得南加州大学旅游奖,洛杉矶病理学会论文优秀奖,并受邀参加过多个国内和国际会议。现为美国加拿大病理学会,美国临床科学家协会, 中美病理协会会员。

Peer Reviewed publications:

Wang L, Shao B, Yan Y. Anti-inflammatory and analgesic actin of 3B-C1. Chinese Pharmacological Communication 3-4:220-1, 1984

Wang L, Yan Y. Primary studies on anti-inflammatory effects of crystals of rabdosiasawlponeata (Vaniot) Hava. Communication of Special Society of National Anti-inflammatory and Immunology Pharmacology 26:6, 1985

Liu L, Wang L, Ganz T. Structure and mapping of the human β-defensin HBD-2 gene and its expression at the site of inflammation. Gene 222:273-244, 1998

Wang L, Tabbarah HJ, French SW. Gastric adenocarcinoma with a yolk sac component: A case report and review of the literature. J Clin Gastroenterology 31(1):85-8, 2000

Wang L, Vargas H, French SW. Cellular origin of gastrointestinal stromal tumors. Arch Pathol Lab Med 124(10):1471-5, 2000

Egger B, Cai NN, Wang L, French SW, Bucher MW, Eysselein VE. Transforming growth factor-alpha (TGF-α) is not needed for malignant transformation in experimental colitis. Scand J Gastroenterology 36:276-282, 2001

Wang X, Morgan T, Lungo W, Wang L, French SW. Piecemeal necrosis: Renamed Troxis Necrosis. ExpMolPathol 71:137-146, 2001

Wang L, Cornford M. Coincident choroid plexus carcinoma and adenocortical carcinoma with elevated p53 expression: A case report of an 18-month-old boy with no family history of cancer. Arch Pathol Lab Med 126(1):70-73, 2002

Wang L, Ohara JA, Cote RJ. Pathology quiz case: 41-year-old woman with bilateral nodular breasts. Arch Pathol Lab Med 126(2):223-4, 2002

Wang L, Felix JC, Lee JL, Tan PY, Tourgeman DE, O’Meara AT, Amezcua CA. The proto-oncogene c-kit is expressed in leiomyosarcomas of the uterus. Gynecologic Oncology 90:402-6, 2003

Ching B, Klink A, Wang L. Pathology quiz case: 22-year-old female with a large right adnexal mass. Arch Pathol Lab Med 128(7):93-95, 2004

Choi H, Cornford ME, Wang L, Sun J, Friedman TC. Suprasellar mass with panhypopituitarism in acute Chagas disease. Pituitary 7:111-114, 2004

Wang L, Sherrod A, Warner N. Pathology quiz case: 79-year-old woman with a black, ulcerated cecal tumor and three negative Guaiac test results. Arch Pathol Lab Med 129(1):113-4, 2005

Zhang Q, Oh CK, Messadi DV, Duong HS, Kelly AP, Soo C, Wang L, Le AD. Hypoxia-induced HIF-1 an accumulation is augmented in a co-culture of keloid fibroblasts and human mast cells: Involvement of ERK1/2 and PI-3K/AKt. Exp Cell Res. 312(2):145-55, Jan 15 2006

Zhang Q, Kelly AP,Wang L, French SW, Tang X, Duong HS, Messadi DV, Le AD. Green Tea Extract and (-)-Epigallocatechin-3-gallate Inhibit Mast cell-stimulated Type I Collagen Expression in Keloid Fibroblasts via Blocking PI-3K/Akt Signaling Pathway. J Invest Dermatol. 126(12):2607-13, Dec 2006. Epub Jul 13, 2006

Ghoneum M, Wang L, Agrawal S, Gollapudi.S. Yeast therapy for the treatment of breast cancer: a nude mice model study. In vivo 21:251-258, 2007

Zhang Q, Yamaza T, Kelly AP, Shi S, Wang S, Brown J, Wang L, French SW, Shi S, Le AD. Tumor-Like Stem Cells Derived from Human Keloid Are Governed by the Inflammatory Niche Driven by IL-17/IL-6 Axis. PloS ONE 4 (11): e7798. Pages 1-32, Nov 11 2009

Whang TB, Wang L, Peng DH. Gastric carcinoma of the umbilicus: case report of sister mary nodule. Cutis 85:90-92, 2010

Xu T, He K, Wang L, Goldkorn A. Prostate tumor cell with cancer progenitor properties have high telomerase activity and rapidly killed by telomerase interference. Prostate. Feb. 2011. Published online in Wiley Online Library, DOI 10.1022/pros.

Fairey AS, Daneshmand S, Wang L, Schuckman A, Lieskovsky G, Djaladat H, Cai J, Miranda G, Skinner EC. Impact of micropapillaryurothelial carcinoma variant histology on survival after radical cystectomy.Urologic Oncology http://www.researchgate.net/journal/1873-2496_Urologic_Oncology(Impact Factor: 3.65). 03/2013; DOI:10.1016/j.urolonc.2012.04.020

Abstracts:

Wang L, Shao B, Yan Y. Anti-inflammatory and immunology inhibitory effects of Sedoprosanum, 5th Southeast Asian and Western Pacific Regional Meeting of Pharmacologists, Beijing, China, July 4-8, 1988 (Poster presentation)

Edelstein MA, Sze GS, Wang L, French SW, Eysselein VE, Vargas H.Endoscopic ultrasonography (EUS) staging of primary gastric adenocarcinoma (G1744). Gastroenterology 116:4 Part 2: A398, 1999 (Poster)

Khaleg AM, Sze GS, Eysselein VE, Wang L, French SW. An algorithm for staging pancreatic adenocarcinoma and predicting resectability using endosonography (EUS) (G1911). Gastroenterology 116:4 Part 2:A435, 1999 (Poster)

Egger B, Cai NN, Wang L, French SW, Eysselein VE. Transforming growth factor-alpha (TGF-α) is a key mediator in protection and/or repair mechanisms but is not required for tumor formation in murine chronic dextran sulfate colitis (G3067). Gastroenterology 116:4 Part 2:A705, 1999 (Poster)

Wang L, Vargas H, Kakuda J, Wang E, French SW. Origination of gastrointestinal stromal tumors: Study of 23 cases. Am J ClinPathol 112:542-3, 1999 (Poster presentation)

French SW, Lungo W, Wang L, Wang J, Wang X. Piecemeal necrosis in hepatitis C: A morphologic analysis. Hepatology 30(4): 335A, 1999 (Poster)

Wang L, McPhaul L, Felix J, Amezcua C, French SW C-kit expression in smooth muscle tumor. Am J ClinPathol 116:609, 2001 (Poster)

Wang L, Greaves TS, Berberrian K, Cobb CJ.The diagnostic utility of parotid gland FNA as a toll for surgical triage. Lab Invest 82(1): 91A, 2002 (Poster)

Wang L, Felix JC, Amezcua CA. The pattern of expression of c-kit and CD10 may aid in the diagnostic distinction among uterine mesenchymal neoplasms. Lab Invest 82(1): 213A, 2002 (Poster presentation)

Wang L, Williams AS, Groshen S, Nichols PW, Cote R. HER-2/neu expression in bladder micropapillary transitional cell carcinoma: A potential target for therapy. Am J ClinPathol 118:657-8, 2002 (Poster)

Wang L, Messadi D, Kelly P, Le A, French SW. Role of mast cells in keloid pathogenesis. United States and Canadian Academy of Pathology 93rd Annual Meeting, Vancouver, BC, Canada, March 6-12, 2004

Vu TH, Wang L, Liu RW, Sun J. A tale of two tumors. Los Angeles Radiology Society Annual Midwinter Meeting, February 2004 (Poster)

Liu RW, Sun J, Owens J, Vu TH, Wang L. Chondrosarcoma of the skull base. Los Angeles Radiology Society Annual Midwinter Meeting, February 2004 (Poster)

Bolton D, Wang L, Klink A, Liu RW, Vu TH. Rhabdomyosarcoma: A nineteen-year-old female presenting with respiratory failure. Los Angeles Radiology Society Annual Midwinter Meeting, February 2004 (Poster)

Ching B, Klink A, Wang L. 22-year-old female with a large right adnexal mass. Los Angeles Radiology Society Annual Midwinter Meeting, February 2004 (Poster)

Zhang Q, Tang X, Duong HS, Kelly AP, Soo C, Wang L, Le AD. Altered functions of keloid fibroblasts co-cultured with mast cells under both normoxic and hypoxic conditions. October 2005 (Poster)

Wang L, Zhang Q, Kelly AP,French SW, Tang X, Duong HS, Messadi DV, Le DV. Green tea extract and (-)-epigallocatechin-3- gallate inhibit mast cell-stimulated type I collagen expression in keloid fibroblasts via blocking PI-3K/Akt signaling pathway. The Pathologists’meeting CAP 2006 in San Diego, California, 2006 (Poster presentation)

Chan V and Wang L. Signet ring cell sinus histiocytosis of lymph node mimicking metastatic signet ring cell adenocarcinoma. The Pathologists’ meeting CAP 2007, Chicago, IL, Sept. 30-Oct. 3, 2007 (Poster)

Fairey AS, Yang D, Groshen SG, Kim P, Virk N, Wang L, Martin SE, Stephens C, Cooc J, Goldkorn A. Association between cancer stem-like cell gene expression and clinical outcome in localized prostate cancer: A nested case-control study. 2012 Genitourinary Cancers Symposium (February 2-4, 2012). Abstract # 89775 (Poster presentation).Received ASCO-GU Merit Award.

Hu BR, Fairey AS, Yang D, Li M, Groshen SG, Stephens C, Quinn ID, Kim P, Virk N, Wang L, Martin SE, Gill SI, Goldkorn A. AXIN2 and prostate cancer recurrence after radical prostatectomy. 2014 Genitourinary Cancers Symposium (January 30-February 1, 2014 | San Francisco Marriott Marquis | San Francisco, CA Abstract # 123827 (Poster presentation).

Poole B, Wecsler J, Sheth P, Sener SF, Tripathy D, Yamashita M, Wang L, Russell C, Johnson M, Larson l, Lang EL. Contemporary Upgrade Rates on Excisional Breast Biopsy for Radiology-Pathology Discordant Core Biopsies, accepted for a poster presentation at the American

王为 职称:主任医师 擅长:消化、肺、乳腺 单位:Zone 5 Authority/Vitalite Health Networ 病理科

王为老师,1977-1985年就读于山东大学医学院, (原山东医科大学) 获得学士及硕士学位. 1988-1989年前往日本和歌山医科大学接受医用电镜培训。1993-1999年前往加拿大,于里加纳大学攻读博士,和多伦多大学博士后的培训。1999-2003年,于美国Hahnemann/Florida大学完成病理住院医师培训. 2003-2005, 于美国,密歇根底特律Beaumont医院和纽约州Roswell Park肿瘤医院完成输血医学及肿瘤病理住院医后的培训 (fellow)。
2005年,王老师在加拿大New Brunswick第5区医院做病理医生. 2006年至今,王老师担任该院病理系主任.王老师发表过许多文章及书,并在许多医学协会/社团中担任过主席及成员。王老师的临床、教学和研究兴趣包括肿瘤病理、法医学、干细胞临床应用和输血医学。
Dr.Wang, 1977-1985, earned his medical and master degree (class 77) from Shandong Medical University, China. 1988-1989, he went to Japan Wakayama Medical University for medical EM training. 1993-1999, he went to Canada for Ph.D and postdocteroal training at Univ. of Regina and Univ of Toronto. 1999-2005, Dr.Wang completed his pathology resident/fellowship training at Univ. of Hahnemann/Florida, Roswell Cancer Institute in New York State and Beaumont Hospital in Detroit, Michigan, USA.
Since 2005, Dr.Wang has been as a staff pathologist and since 2006 till present, Dr.Wang has been as a medical director/chief for pathology and laboratory service, at Zone 5 Hospital (previous Campbellton Regional Hospital)/Vitalite Health Network, New Brunswick, Canada . Dr.Wang has many publications, books/chapters and has been a chairperson, member of many committees and societies. His clinical practice, teaching and research interests include of oncology pathology, forensic medicine, clinical application of stem cell and transfusion medicine.

王曦 职称:医学博士, Associate Prof 擅长:乳腺、肿瘤外科 单位:罗彻斯特大学病理与实验医学部 病理科

1978.03-1982.12 中山大学医学院 本科
1986.09-1989.08 中山大学医学院 硕士
研究生教育。1997.11-2001.06 西弗吉尼亚摩根敦,西弗吉尼亚大学医院病理科,住院医师
2001.07-2002.06 纽约,纪念Sloan Kettering肿瘤中心,肿瘤外科病理学

研究经历

1982.12-1986.08 中山大学医学院寄生虫系,讲师

1989.08-1991.09 广州医学院中心实验室,研究人员

1991.11-1996.09 马萨诸塞州波士顿,哈佛公共卫生学院,research fellow

1996.09-1997.11 马萨诸塞州波士顿,哈佛公共卫生学院,助理研究员

教育经历

1982.12-1986.08 中山大学医学院寄生虫系,讲师

2002.07至今 纽约,罗彻斯特大学病理系 助理教授

专业会员

美国临床病理学会(ASCP)

美国加拿大病理学会

研究兴趣

激素在乳腺癌发生过程中的作用,包括ER、 PR和AR,与其他癌基因和抑癌基因的相互作用。

出版物

1. Sharlin Johnykutty, Ping Tang, Xi Wang, Dual expression of ER and TAP in normal/benign breast epithelium and TAP down regulation in ER positive breast cancer. Modern Pathology 2009, in press.

2. Xi Wang, Jing Li, Sharlin Johnykutty, Shuyuan Yeh, Reduced Expression of Tocopherol-Associated Protein (TAP/Sec14L2) in human breast cancer. Cancer Investigation 2009, in press.

3. Ming Chen, Xi Wang, Shuyuan Yeh, Sally Radovick, Generation and characterization of a complete null estrogen receptor mouse using Cre/LoxP technology. Molecular and Cellular Biochemistry 321(145-153), 2009.

4. Rochelle Simon, Xi Wang, A46 XY Phenotypic female adolescent with bilateral gonadal tumors consisting of five different components. International Journal of Gynecological Pathology 27(407-411), 2008

5. Ping Tang, Xi Wang, Linda Schiffhauer, Jianmin Wang, Patricia Bourne, Qi Yang, Andrew Quinn, and Steven Hajdu, Expression Patterns of ER-a, PR, Her2/neu and EGFR in different cell origin subtypes of high grade and non-high grade ductal carcinoma in situ. Annals of clinical & laboratory science 36(2), 2006

6. Ping Tang, Xi Wang, Linda Schiffhauer, Steven Hajdu, Relationship between nuclear grade of ductal carcinoma in situ and cell origin markers. Annals of clinical & laboratory science 36(1), 2006

7. Jakob Dupont, Xi Wang, Robert Soslow, Wilms tumor gene (WT1) and p53 expression in endometrial carcinomas: a study of 130 cases using tissue microarrays. Gynecologic Oncology 94(2), 2004.

8. Xi Wang and Sharon L. Wenger, Multiple chromosome abnormalities following bone marrow transplant for chronic myelogenous leukemia. The Journal of the Association of Genetic Technologists 30 (1), 2004

9. Xi Wang, David C. Christiani, Eugene J. Mark, Karl T. Kelsey, Carcinogen exposure, p53 alteration and K-ras mutation in synchronous multiple primary lung cancers. Cancer 1998

10. Xi Wang, Kathleen M. Egan, Evangelos S. Gragoudas, Karl T. Kelsey, Constitutional alterations in p16 in patients with uveal melanoma. Melanoma Research Vol. 6 405-410, Dec. 1996

11. Karl T. Kelsey, Heather Nelson, Xi Wang, Lung carcinogenesis: molecular and cellular mechanisms. Occupational Lung Disease. Thomson Science & Professional, 1997

12. Xi Wang, David C. Christiani, John K. Wiencke, Eugene J. Mark, Karl T. Kelsey, Mutations in the p53 gene in lung cancer are associated with cigarette smoking and asbestos exposure. Cancer Epidemiology, Biomarkers & Prevention. Vol. 4, 543-548, July/August 1995

13. Fen Xia, Xi Wang, David W Yandell, Howard L. Liber. Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines. Cancer research Vol 55, 12-15, January 1, 1995

14. C. Mark Smith, Xi Wang, Howard Hu, and Karl T. Kelsey, A polymorphism in the -aminolevulinic acid dehydratase gene may modify the pharmacokinetics and toxicity of lead. Environmental Health Perspectives. Vol. 103, 248-253, Mar. 1995

演讲

1. Joseph Weisensel and Xi Wang, Estrogen receptor (ER) and androgen receptor (AR) in normal human breast tissue and breast carcinoma. USCAP 2009, Boston, MA

2. Sharlin Johnykutty and Xi Wang, Spindle cell (sarcomatous) carcinoma of the breast: Immunohistochemical profile and the clinical outcome. USCAP 2009, Boston, MA

3. Sharlin Johnykutty, Xi Wang, Dual expression of alpha=Tocopherol Associated Protein (TAP) and ER in normal human breast epithelium and its down regulation in ER positive breast carcinomas. USCAP, Danver, CO, 2008

4. Sharlin Johnykutty, Xi Wang, Reduced TAP expression in human breast cancer. USCAP, San Diego, CA, 2007

5. Xi Wang, Jacob Dupunt, Robert Soslow, WT1 expression in ovarian and endometrial carcinomas using tissue microarrays. Annual meeting of United States and Canadian Academy of Pathology, 2003, Washington, DC

6. Xi Wang, et al, P53 mutational analysis indicating that small cell and non-small cell carcinoma of the lung have a common histogenesis. Eighty-eighth Annual Meeting of American Association for Cancer Research (AACR), San Diego, CA, 1997

7. Xi Wang, et al, p53 mutational status in lung cancer patients with multiple primary tumors. Eighty seventh Annual Meeting of AACR, Washington, DC, 1996

8. Xi Wang, et al, Polymorphism in carcinogen activating genes are associated with the absence of mutations in the p53 gene in lung cancer. Eighty- seventh Annual Meeting of AACR, Washington, DC, 1996

9. Xi Wang, et al, Mutations in the p53 gene in non-small cell lung cancer are associated with cigarette smoking and asbestos exposure. Eighty sixth Annual meeting of AACR, Toronto, Canada, 1995

10. Xi Wang, et al, The mutational spectra of p53 in human lung cancer. Eighty-fifth Annual Meeting of AACR, San Francisco, CA, 1994

徐浩东 职称:教授 擅长:纵膈肺、心脏、免疫 单位:加州大学洛杉矶分校大卫格芬医学院 病理科

加州大学洛杉矶分校大卫格芬医学院,病理学与实验医学部教授.

教育背景:

本科:苏州大学医学院,9/1982-8/1987

硕士:苏州大学医学院,方向:循环生理学,9/1987-7/1990

博士:苏州大学医学院,方向:心脏生理学,9/1990-7/1993
学术职位职务:
7-9/1990; 9-11/1993
Research Fellow 苏州大学医学院第一附属医院心内科
11/1993-6/1999
博士后,美国华盛顿大学医学院,分子生物学和药理学
7/1999-6/2001
解剖病理学住院医师,美国华盛顿大学医学院,病理学与免疫学系
7/2001-6/2002
住院医师和博士后,美国华盛顿大学医学院,病理学与免疫学系
研究领域:KChIP2 和丝蛋白 C在小鼠心室肌细胞电压门控钾通道产生中的作用
7/2002-6/2003
解剖病理学住院医师,美国华盛顿大学医学院,病理学与免疫学系
7/2003-6/2004
Fellow,美国华盛顿武装部队病理学研究所,肺与纵隔病理学系
7/2004-4/2008
助理教授,美国罗彻斯特大学医学与口腔学院,病理学与实验医学部
5/2008- 11/2011
副教授,美国罗彻斯特大学医学与口腔学院,病理学与实验医学部

12/2011- 7/2013

教授,美国罗彻斯特大学医学与口腔学院,病理学与实验医学部

8/2013至今

教授,加州大学洛杉矶分校大卫格芬医学院,病理科和实验医学部

医疗执照与委员会证明:
华盛顿永久执照
纽约永久执照

加利福尼亚州行医执照
解剖病理学委员会认证

专业社团成员:
美国-加拿大病理学会
美国心脏病学会

中美病理家协会 副会长(3/2012-3/2013)

编委会成员:
人体病理学杂志

免疫组化和分子学应用杂志

生物医学和生物技术杂志

世界消化道肿瘤杂志

中国临床医学杂志

临床与实验病理学杂志

组织学与组织病理学

中国现代医学杂志

临床专长:
外科病理学,尤其是肺和纵隔病理学,心脏病理学,和免疫组织化学

研究兴趣:基础科学:
定义了p90RSK激活延长心脏复极化及其在心律失常发展中发挥重要作用的分子机制

临床translational研究:
确定恶性肿瘤中癌蛋白的表达方式,特别是肺癌,鉴别用于诊断和预后的有用的生物学标记

专业服务:
罗彻斯特大学医学中心生物医学和健康科学毕业生程序成员
期刊杂志评审小组成员,范围包括人类病理学,应用免疫组织化学和分子形态学,外科病理学国际性期刊

奖励和荣誉:
“优秀学生奖学金”,苏州大学医学院(1982-1987)
班长,苏州大学医学院(1982-1987)
Zhou, Wenxun奖学金(1992)
硕士班长(1987-1990)
论文获第六届心脏起搏与电生理学研讨会“杰出青年论文奖”, 中国武汉,10.19-21, 1992.
论文获第四届心脏病学研讨会“优秀论文奖”,中国西安,10 .14-16, 1993
NIH“膜片钳技术应用”三等奖,中国,1996
NIH心血管训练奖助金(10. 1997-6.1999)
NIH心血管训练奖助金(7, 1, 2001-6, 30, 2002)
Culpeper基金,合作研究,“磁共振成像识别冠状动脉瓣膜破裂倾向”, PI: Jie Zheng博士 (1, 1, 2002-12, 31, 2002)

华夏病理学教学奖(2010年)

病理与实验医学部Eric A. Schenk优秀老师(2010)

现有奖助金:
NIH R01奖助金,PI“Wnt/β-catenin 信号和 心脏 Na+通路” (1/1/2015–1/1/ 2020).

AHA Grant-in-Aid,PI“ ROS介导抑制NaV1.5中Foxo1的作用”(1/1/2012-12/31/2014 )

NIH R01奖助金,合作研究,"细胞特异性基因和药物传递的DNA核序列导入"(9/30/2010- 8/31/2014 )
NIH K08奖助金,PI,“激酶对Ito,f的调节在心律异常中的作用” (8/15/2007–4/ 30/ 2012).
NIH R01奖助金,合作研究(PI: Chen Yan) “磷酸二酯酶在心脏中的调节与功能” (12/1/2007 – 11/30/2012)
科学与健康研究所奖助金,合作研究(PI: Irfan Rahman),“慢性阻塞性肺疾病中吸烟相关肺部炎症的分子机制” (7/1/2008 – 6/30/2011).

教育贡献:
大二医学生生理学,苏州大学医学院,1988
大三医学生心电图学,苏州大学医学院,1990

罗彻斯特大学医学中心教学贡献如下:
病理学住院医师教学:
5-6小时/天,外科病理学签发
3-4小时/天,冰冻切片
每年6次,一小时讨论会,大体与冰冻切片诊断技术
每年2次,一小时讲座,解剖教学(肺与纵隔病理学)

医学生:
常年病理住院医师教学
偶尔参加病理实验室会议

博士生:
每年2次,一小时演讲,心血管生物学课程(心脏解剖与发育,心律失常)
每年2次,两小时演讲,病理学课程(心脏病理学,心脏电生理学)

指导医师临床translational研究:
细胞病理学医师、住院医师和医学生参与过我的临床translational研究。我对方案提出意见,并帮助设计方案,撰写草稿。他们当中大部分均在USCAP会议上发表过摘要,并以第一作者发表过论文和/或摘要。(见出版物)

指导博士后和大学生基础研究:
博士后Zhibo Lu随我一起工作两年多。他在我们部门研究期间两次提出数据。2007年他在佛罗里达州奥兰多市的AHA科学研讨会上发表了我们的摘要。
罗彻斯特大学四年级学生Sheng Ping Xu随我一同工作两个多月。他学习了分子生物学的一些基本技术,为实验室配置缓冲液。

同行评议稿:

1. Huang WQ, Zhao, WW, Xu H, Xu B and Yu ZM. Comparison of effects of 4 anesthetics on carotid sinus reflex in rats. Chinese Journal of Applied Physiology 7:227-232 (1991).
2. Huang, WQ, Xu H, Wu X, Xu B and Yu ZM. Role of the central a receptors in the modulation of carotid reflex of rats. Sheng Li Xue Bao 44:556-561 (1992).
3. Xu H, Huang WQ, Zhao WW, Xu, B and Yu ZM. Effect of the central noradrenergic system of carotid sinus reflex in rats. Sheng Li Xue Bao 44:127-132 (1992).
4. Xu H and Jiang WP. Recording potassium, calcium and sodium currents of ventricular cells using patch-clamp technique. Pace and Heart (Chinese) 7:9-11 (1993).
5. Jiang WP and Xu H. Studies of activity of ionic channels and its applications. Zhonghua Xin Xue Guan Bing Za Zhi 22:55-56 (1994).
6. Xu H, Qiu CG and Jiang WP. Studies on electrophysiology of lysophosphatidylcholine and evaluation of its clinical significance. Zhonghua Nei Ke Za Zhi 33:519-523 (1994).
7. Xu H, Dixon JE, Barry DM, Trimmer JS, McKinnon D, Merlie JP and Nerbonne JM. Developmental analysis reveals mismatch in the expression of K+ channel a subunits and voltage-gated K+ channel currents in rat ventricular myocytes. Journal of General Physiology 40:444-478 (1996).
8. Barry DM, Xu H, Schuessler RB and Nerbonne JM. Functional knockout of the cardiac transient outward K+ current in mice expressing a dominant negative voltage-gated K+ channel (Kv4) a subunit. Circulation Research 83:560-567 (1998).
9. Xu H, Li H and Nerbonne JM. Elimination of the transient outward current and action potential prolongation in mouse atrial myocytes expressing a dominant negative Kv4 a subunit. Journal of Physiology 519:11-21 (1999).
10. Xu H, Guo W and Nerbonne JM. Four kinetically distinct depolarization-activated K+ currents in adult mouse ventricular myocytes. Journal of General Physiology 113: 661-677 (1999).
11. Guo W, Xu H, London B and Nerbonne JM. Molecular basis of transient outward K+ current diversity in mouse ventricular myocytes. Journal of Physiology 521:587-599 (1999).
12. Xu H, Barry MD, Li H, Brunet S, Guo W and Nerbonne JM. Attenuation of the slow component of delay rectification, action potential prolongation, and triggered activity in mice expressing a dominant-negative Kv2 a subunit. Circulation Research 85:623-633 (1999).
13. Li H, Guo W, Xu H, and Nerbonne JM. Functional expression of a GFP-tagged Kv1.5 a subunit in mouse ventricle. American Journal of Physiology-Heart 281:H955-967 (2001).
14. Sundt TM, Moon MR and Xu H. Reoperation for dilatation of the pulmonary autograft after Ross procedure. Journal of Thoracic and Cardiovascular Surgery 122:1249-1252 (2001).
15. Goldstein JA, Beardslee MA, Xu H, Sundt TM and Lasala J. Infective endocarditis on a CardioSEAL Device closing a patent formen ovale. Catheterization and Cardiovascular Interventions. 55:217-220 (2002).
16. Okamato R, Xu H, Kouchoukos N, Moon MR and Sundt TM. The influence of medical properties on wall stress and distensibility of the dilated ascending aorta. Journal of Thoracic and Cardiovascular Surgery 126:842-850 (2003).
17. Xu H, Lu D, EL-Mofty SK and Wang H. Metachronous squamous cell carcinomas evolving from independent oropharyngeal and pulmonary squamous papillomas: associated with human papillomavirus 11 and lack of aberrant p53, Rb and p16 protein expression. Human Pathology 5:1419-1422 (2004).
18. Chiu HC, Kovacs A, Blanton RM, Han X, Courtois M, Weinheimer CJ, Yamada KA, Brunet S, Xu H, Nerbonne JM, Welch MJ, Fettig NM, Sharp TL, Sambandam N, Olson KM, Ory DS and Schaffer JE. Transgenic expression of FATP1 in the heart causes lipotoxic cardiomyopathy.
Circulation Research 96:225-233 (2005).
19. Ding B, Abe JI, Wei H, Xu H, Che W, Aizawa T, Liu W, Molina CA, Sadoshima J, Blaxall BC, Berk BC and Yan C. A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis. Proceedings of the National Academy of Sciences 102:14771-14776 (2005).
20. Guo W, Tung WE, Marionneau C, Aimond F, Xu H, Yamada KA, Schwartz TL, Demolombe S and Nerbonne JM. Targeted deletion of Kv4.2 eliminates Ito,f and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction. Circulation Research 97: 1342-1350 (2005).
21. Bhagwat SP, Gigliotti F, Xu H and Wright TW. Contribution of T cell subsets to the pathophysiology of pneumocystis-related immunorestitution disease. American Journal Physiology-Lung Cell Mol Physiol 291:L1256-66 (2006).
22. Shah AP, Xu H, P.J. Sime PJ and Trawick DR. Severe airflow obstruction and eosinophilic lung disease after Stevens-Johnson syndrome. European Respiratory Journal 28:1276-1279 (2006).
23. Wagner D, Joseph J, Huang J and Xu H*. Malakoplakia of the prostate on needle core biopsy: a case report and review of the literature. The International Journal of Surgical Pathology 15: 86-89 (2007).
24. Hameed O, Xu H, Saddeghi S and Maluf H. Pancreatic neuroendocrine carcinoma with prominent hepatocellular differentiation. American Journal Surgical pathology 31:146-152 (2007).
26. Xu H*, Bourne PA, Spaulding BO and Wang HL. High grade neuroendocrine carcinomas of the lung express K homology domain containing protein overexpressed in cancer (KOC) but carcinoid tumors do not. Human Pathology 38:556-563 (2007).
27. Ishinaga H, Jono H, Jae Hyang Lim JH, Kweon SM, Xu H, Ha UH, Xu H, Feng XH, Chen LF and Jian-Dong Li JD. TGF-b induces p65 acetylation to enhance Bacteria-induced NF-kB activation. EMBO Journal 26:1150-1162 (2007).
28. Yan C, Ding B, Shishido T, Woo CH, Itoh S, Jeon KI, Liu W, Xu H, McClain C, Molina CA, Blaxall BC, and Abe JI. Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop. Circulation Research 100: 510-519 (2007).
29. Simon R, Bourne PA, Yang Q, Spaulding BO, di Sant'Agnese PA, Wang HL and Xu H*. Extrapulmonary small cell carcinomas express K homology domain containing protein overexpressed in cancer (KOC) but carcinoid tumors do not. Human Pathology 38:1178-1183 (2007).
30. Lim JH, Stirling B, Derry J, Koga, T, Jono H, Woo CH, Xu H, Bourne PA, Ha UH, Ishinaga H, Xu H, Andalibi, A, Feng XH, Zhu H, Huang Y, Zhang W, Weng X, Yan C, Yin Z, Briles DE, Davis RJ, Flavell RA and Li JD. Tumor suppressor CYLD acts as a crucial regulator of acute lung injury in lethal streptococcus pneumoniae infections. Immunity 27: 249-60 (2007).
31. Miyamoto H, Molena DA, Schoeniger LO, and Xu H*. Solitary fibrous tumor of the pancreas: a case report. International Journal of Surgical Pathology 15: 311- 314 (2007).
32. Lim JH, Jono H, Koga T, Woo CH, Ishinaga H, Bourne P, Xu H, Ha UH, Xu H, Li JD.Tumor Suppressor CYLD Acts as a Negative Regulator for Non-Typeable Haemophilus influenza-Induced Inflammation in the Middle Ear and Lung of Mice. PLoS ONE.10; e1032 (2007).
33. LaPoint RJA, Bourne PA, Wang HL and Xu H*. Coexpression of c-kit and bcl-2 in small cell carcinoma and large cell neuroendocrine carcinoma of the lung. Applied Immunohistochemistry & Molecular Morphology, 15:401-406 (2007).
34. Hanley KZ, Facik MS, Bourne, PA, Yang Q, Spaulding, BO, Bonfiglio, TA and Xu H*. Utility of Anti-L523S Antibody in the Diagnosis of Benign malignant serous effusions. Cancer Cytopathology 25;114:49-56 (2008).
35. Pryor JG, Bourne PA, Yang Q, Spaulding BO, Scott GA and Xu H*. IMP3 is a progression marker in malignant melanoma. Modern pathology 21:431-437(2008).
36. Wagner D, Bourne PA, Yang Q, Goldman BI, Lewis, JS, and Xu H*. Unusual features of malignant pleural mesothelioma metastatic to the mediastinal lymph nodes. Applied Immunohistochemistry and Molecular Morphology, in press.
37. Lester, T and Xu H*. Malignant pleural mesothelioma with osseousmetastases and pathologic fracture of femoral neck: a case report. Applied Immunohistochemistry and Molecular Morphology. in press.
38. Li L, Xu H, Spaulding BO, Cheng L, Simon R, Yao JL, P. Anthony di Sant’Agnese AP, Patricia A. Bourne, PA and Huang J. Expression of KOC (K-domain protein overexpressed in human cancer) in benign urothelium and urothelial tumors. Human Pathology. in press.
39. Miyamoto H, Jones CE, Raymond DP, Strang J, Wandtke JC, Bourne PA and Xu H*. Pulmonary metastases from uterine neoplasms after long tumor-free interval: Four cases and review of the literature. Pathology. in press.
40. Lu Z, Abe JI, Taunton J, Schishido, T McClain C, Yan C, Xu SP and Xu H*. Reactive oxygen species-Induced p90 ribosomal S6 kinase activation leads to prolongation of cardiac repolarization via Inhibiting voltage-gated outward K+ currents. Circulation Research. in revision.
41. Fallone E, Bourne PA, Watson TJ, Ghossein R, Travis WD and Xu H*. Parathyroid adenoma with prominent lymphocytic infiltration in the mediastinum. Applied Immunohistochemistry and Molecular Morphology. in revision.
42. Simon RA, di Sant’Agnese PA, Xu H, Yao JL, Qi Y, Bourne PA, Liang S, Liu J, Wei J, Cheng L, Oh WK and Huang J. CD44 expression is a feature of prostatic small cell carcinoma and distinguishes it from its mimickers. Submitted to Clinical Cancer Research.
43. Pryor JG, Simon RA, Bourne PA, Spaulding BO, Scott GA and Xu H*. Merkel cell carcinomas express K homology domain containing protein overexpressed in cancer similar to other high-grade neuroendocrine carcinomas. Submitted to Human Pathology.
44. Ling C, Ji C, Raymond PA, Bourne PA and Xu H*. Unusual features of pulmonary Langerhans’ cell histiocytosis. Submitted to Human Pathology.

(*通讯作者)

书籍章回:

1. Xu H and Wang HL. Small cell carcinoma of the uterine cervix: a sibling of
small cell lung carcinoma? In: New Research on Cervical Cancer. Rolland
GZ, eds, Nova Science Publishers, Inc., Hauppauge, NY. 2007, pp 109-127.
2. Xu H and Wang HL. Cytomegalovirus and human cancers. In: Oncogenic
Virus. Tunely EI, eds, Nova Science Publishers, Inc., Hauppauge, NY. 2007, pp 215-245.

摘要:

1. Xu H, Barry DM, Trimmer JS, Merlie JP and Nerbonne JM. Differential expression of voltage-gated K+ channel subunits and functional K+ channels during postnatal development. Circulation 92:I-372 (1995).
2. Xu H, Barry DM and Nerbonne JM. Molecular correlates of functional Ito and IK channels in rat ventricular myocytes probed with K+ channel toxins and antisense oligonucleotides. Circulation 96:I-421 (1997).
3. Barry DM, Xu H and Nerbonne JM. The Kv4 subfamily contributes to the peak outward K+ current in mouse ventricular myocytes. Circulation 96:I-422 (1997).
4. Barry DM, Xu H and Nerbonne JM. Functional knockout of the cardiac transient outward K+ current in mice expressing a dominant negative voltage-gated K+ channel (Kv4) a subunit. Biophysical Journal 74:A27 (1998).
5. Xu H and Nerbonne JM. Functional knockout of the atrial transient outward K+ current in mice expressing a dominant negative Kv4 a subunit. Circulation 98:I-610 (1998).
6. Xu H, Barry MD, LI H, Bourne S, Guo W and Nerbonne JM. Two distinct components of the slowly inactivating K+ current, IK,slow in mouse ventricular myocytes: a role for Kv2 a subunits. Circulation 100:I351 (1999).
7. Li H, Xu H and Nerbonne JM. Functional expression of a GFP-tagged Kv1.5 a subunit in cardiac myocytes of transgenic mouse. Circulation 100:I-633 (1999).
8. Xu H, Franks TJ, Galvin JR and Travis WD. The impact of chest imaging on the pathologic diagnosis of pulmonary, mediastinal, and pleural disease. Modern Pathology 17 (Supplemental I):345A (2004).
9. LaPoint R JA, Bourne PA, Wang HL and Xu H. Coexpression of c-kit and
bcl-2 in small cell carcinoma and large cell neuroendocrine carcinoma of the lung. Modern Pathology 19:312A (2006).
10. Shishido T, Woo CH, Ding B, McClain, Lu Z, Xu H, Yan C, Abe JI. Angiotensin II and reactive oxygen species (ROS) induce ERK5-SUMOylation and inhibit ERK5 transcriptional activity: impact in diabetic cardiomyopathy (DMC). Circulation 114 (Supplement II):II-84 (2006).
11. Xu H, Bourne PA, Spaulding BO and Wang HL. K homology domain containing protein overexpressed in cancer (KOC) is highly expressed in small and large cell neuroendocrine carcinomas but not in carcinoid tumors of the lung. Modern Pathology 20 (Supplement II):334A (2007).
12. Hanley KZ, Facik MS, Bourne PA, Spaulding BO, Bonfiglio TA and Xu H. Utility of anti-L523S antibody in the diagnosis of benign and malignant pleural effusion. Modern Pathology 20 (Supplement II):334A (2007).
13. Wagner D, Bourne PA, Goldman BI, Lewis, JS Jr. and Xu H. Metastatic malignant pleural mesothelioma in the mediastinal lymph node: a clinico- pathologic-radiologic study of seven cases. Modern Pathology 20 (Supplement II):71A (2007).
14. Pryor JG, Bourne PA, Spaulding BO, Scott GA and Xu H. K homology domain containing protein overexpressed in cancer (KOC) is expressed in malignant melanoma but not in melanocytic nevi. Modern Pathology 20 (Supplement II):98A (2007).
15. Li L, Simon R, Spaulding BO, Bourne PA, Yao JL, di Sant'Agnese PA, Xu H and Huang J. KOC is a useful marker for the classification of urothelial neoplasms of the bladder. Modern Pathology 20 (Supplement II):159A (2007).
16. Shishido T, Woo WH, Ding B, McClain C, Lu Z, Yan C, Xu H and Abe, JI. Blockade of diabetes (DM)-mediated p90RSK activation reduces small ubiquitin-related modification of ERK5 kinase (ERK5-SUMOylation) and DM-induced exacerbation of left ventricular (LV) remodeling after myocardial infarction (MI). Circulation 116: II-101 (2007).
17. Lu Z, Abe J, Taunton J, and Xu H. Reactive oxygen species-induced p90
ribosomal S6 Kinase activation leads to prolongation of cardiac repolarization via inhibiting voltage-gated outward K+ Currents. Circulation 116: II-118 (2007).
18. Shishido T, Woo CH, Ding B, McClain C, Lu B, Xu H, Yan C, and Abe JI. Association of ERK5 with MEK5 (upstream kinase of ERK5), but not ERK5 kinase activation, inhibits small ubiquitin-related modification of ERK5 kinase (ERK5-SUMOylation), and prevents diabetes (DM)-mediated exacerbation of left ventricular (LV) remodeling After myocardial infarction (MI). Circulation 116: II-211 (2007).
17. Xu H, Briones AJ, Bourne PA, Spaulding BO, Lu D, Fischer-Colbrie R, Qu Z and Wang HL. KOC, TTF-1 and CDX2 discriminate small cell carcinoma from carcinoid and pancreatic endocrine tumor metastasized to the liver. Modern Pathology 21 (Supplement I):318A (2008).
18. Briones AJ, Bourne PA, Spaulding BO, Lu D, Fischer-Colbrie R, Qu Z, Wang HL and Xu H. Metastatic pancreatic endocrine tumors in the liver express KOC. Modern Pathology 21 (Supplement I):300A (2008).
20. H Xu, R Simon, Bourne PA, Spaulding BO and Wang HL. immunohistochemical analysis of KOC/IMP3 in malignant pleural mesothelioma. Modern Pathology. in press.
21. Miyamoto H, Bourne PA, Qu Z, Yao Y, Wang HL and Xu H. Diagnostic utility of WT1 immunostaining in gastrointestinal stromal tumor. Modern Pathology 21 (Supplement I):130A (2008).
22. Pryor JG, Simon R, Bourne PA, Spaulding BO, Scott GA and Xu H. Merkel cell carcinomas express K homology domain containing protein overexpressed in cancer like small cell carcinomas Modern Pathology 21 (Supplement I):100A (2008).
23. Simon R, Xu H, Bourne PA, Yao JL, Wei J, Liang S, Liu J, di Sant’Agnese, L Cheng and Huang J. CD44 is a useful marker for prostatic small cell carcinoma. Modern Pathology 21 (Supplement I):182A (2008).
24. Kobel M, Xu H, Bourne PA, Spaulding BO, Huntsman D, Gilks CB. IMP3 is an extremely poor prognosis marker for ovarian clear cell carcinoma. Modern Pathology 21 (Supplement I):209A (2008).
25. H Xu, Simon R, Bourne PA, Spaulding BO and Wang HL. Immunohistochemical analysis of KOC/IMP3 in malignant pleural mesothelioma. Modern Pathology 21 (Supplement I):353A (2008).


26. Chuang C, Raymond, Wandtke JC and H Xu.Pathology and PET-FDG correlation studies determine false positive and negative

milignancies of the lung. Modern Pathology 22 (Supplement I):353A (2009).

27. Mentrikoski MJ, Ma, L, Pryor, JG, McMahon LA, Spaulding BO, Scott GA,Wang HL and Xu H. Diagnostic utility of IMP3 in

segregating metastatic malignant melanomas from benign nevi in lymphnodes. Modern Pathology 22 (Supplement I):351A (2009).

28. Wagner DG, Yang Q, McMahon LA,Spaulding BO, Wang HL and Xu H. IMP3 expression can distinguish hepatocellular

carcinoma from hepatocellular adenoma. Modern Pathology 22 (Supplement I):325A(2009).

29. Wagner DG, Yang Q, McMahon LA,Spaulding BO, Wang HL and Xu H. IMP3 expression can distinguish cholangiocarcinoma

and metastatic pancreatic ductal carcinoma from benign ductal lesions. Modern Pathology 22 (Supplement I):324A (2009).

30. Findeis-Hosey J, Huang J, Li F, Yang Q,McMahon LA and Xu H. High grade neuroendocrine carcinomas of the lung highly

express EZH2 but carcinoids do not. Modern Pathology 22 (Supplement I):350A(2009).

31. Levy M, Lin F, Xu H, DhallD, Spaulding BO, and WangHL. S100P, von HippelLindau gene product (pVHL) and IMP3 serve asa useful immunohistochemical panel in helping diagnose adenocarcinoma on endoscopic bile duct biopsy. Modern Pathology 22 (Supplement I):314A (2009).

32. Chiles L, Levy M, Balzer, B, Xu H, Xiao SY, Zhai J, Soffer, Conklin EJ, Dhall D, Amin MB and WangHL. Characterization of expression of a novel smooth muscle contractile protein smoothelin in gastrointestinal tract: implication in the pathogenesis of chronic intestinal pseudoobstruction. Modern Pathology 22 (Supplement I):126A (2009).

33. Levy M, Dhall D, Zhang J, Miles L,Misdraji J, Yerian LM, Xu Hand Wang HL. Expression of glypican-3 in embryonal

sarcoma and mesenchymal hamartoma of the liver: A potential diagnostic pitfall.Modern Pathology 22 (Supplement I):314A (2009).

34. MentrikoskiMJ, ZhaoC, ZhangJ, WangHL,McMahonLA, YangQ, LiF and Xu H.Metastatic endometrial stromal sarcoma in the

lung: importance of immunohistochemical staining, clinical history and imaging studies. Modern Pathology23 (Supplement 1):409A (2010).

35. Li F, Wang X, McMahon LA, Yang Q and Xu H. Minute nests of neuroendocrine cells in the mediastinal lymph nodes: real metastasis? Modern Pathology 23 (Supplement 1):407A (2010).

36. Ye J, Findeis-Hosey JJ, McMahon LA,Yang Q, Li F and Xu H. Usefulness of Napsin A and TTF-1 in discriminating metastatic carcinoma from primary adenocarcinoma of the lung.Modern Pathology 23 (Supplement 1):415A-416A (2010).

37. Findeis-Hosey JJ, Yang Q, McMahon, LA,Spaulding BO, F Li and Xu H. IMP3: An immunohistochemical marker for invasive

squamous cell carcinoma and Its high-grade precursor lesions of the lung.Modern Pathology 23 (Supplement 1):402A (2010).

38. Findeis-Hosey JJ, Yang Q, McMahon, LA,Spaulding BO, F Li and Xu H. Usefulness of EZH2 and IMP3 in discriminating high

grade neuroendocrine carcinoma from carcinoids in small biopsies and fine needle aspiration specimens of the lung. Modern Pathology 23 (Supplement1):401A (2010).

39. Findeis-Hosey JJ, Yang Q, McMahon, LA, F Li and Xu H. Napsin A is frequently expressed in pulmonary adenocarcinoma but rarely detected in neuroendocrine tumors of the lung. Modern Pathology23 (Supplement 1):401A-402A (2010).

40. Thunnissen E, Beasly M, BorczukA, BrambillaE, ChirieacLR, FliederD,GazdarA, KeisingerK, HasletonP, IshikawaY, KerrK, atsunoY, MinamiY, MoreiraA,MotoiN, NicholsonA, NoguchiM, NonakaD, PelosiG, PetersenI, RekhtmanN, RoggliV, TravisB,TsaoM, WistubaI, XuH, Yatabe Y andKuikJ. Reproducibility of histopathological subtypes in pulmonaryadenocarcinoma. An international interobserver study. Modern Pathology 23(Supplement 1):415A (2010).

41. FanLF, Datta V, Riley-PortugesA,LopateguiJ, LinF, XuHand Wang HL. EGFR Expression and KRAS mutation in cholangiocarcinoma: implication in EGFRtargeted therapies. Modern Pathology 23(Supplement 1):354A (2010).

42. Ye B, Xu Hand Li F. Cardiac beta-catenin deletion mediated by alpha-MHC promoter causes ventricular hypoplasia. Circulation 122:A18584 (2010).

43. Mao W, Lu Y, Alexis JD, Li F and Xu H. Foxo1 regulates cardiac sodium channel (NaV1.5) expression in mouse ventricular hypertrophy and failure induced by transverse aortic constriction. Circulation 122:A17271 (2010).

44. Findeis-Hosey JJ, McMahon LA, Yang Qand Li F and Xu H. Increase of EZH2 expression in bronchiolar epithelial cellsin smoking-related diseases of the lung. Modern Pathology 24 (Supplement1):408A-409A (2011).

45. Findeis-Hosey JJ, McMahon LA, Yang Q and Li F and Xu H. EZH2 expression is correlated with histologic grade of lung adenocarcinoma. Modern Pathology 24(Supplement 1):409A (2011).

46. Findeis-Hosey JJ, McMahon LA, Yang Q and Li F and Xu H. EZH2 expression in invasive squamous cell carcinoma of the lung and its precursor lesions.Modern Pathology 24 (Supplement 1):409A (2011).

47. Choy B, Findeis-Hosey JJ,McMahon LA,Yang Q and Li F and Xu H. Coexpression of maspin with p63 and p53 insquamous

cell carcinoma but not in adenocarcinoma of the lung. Modern Pathology 24(Supplement 1):407A (2011).

48. Ye J, Hammed O, Findeis-Hosey JJ, Fan L, Li F, McMahonLA, Yang Q, Wang HLand Xu H. Diagnostic Utility of PAX8, NapsinA and TTF-1 in discriminating metastatic carcinoma from primary non-small cell carcinoma of the lung. Modern Pathology24 (Supplement 1):429A (2011).

49. Lloyd J, Xu Hand Zhao C. CDX2 is a useful marker to distinguish ovarian primary carcinoid from metastasis. Modern Pathology 24 (Supplement 1):258A (2011).

50. Schmidt MT, Chung F, Lin F, Xu, Hand Wang HL. Use of S100P, IMP3 and pVHL immunopanel to aid in the interpretation

of bile duct biopsies with atypical histology or suspicious for malignancy.Modern Pathology 24 (Supplement 1):374A (2011).

51. Ye B, Mao W, McMahon LA, Yang Q, Xu Hand Li F. Chromatin remodeling and cell cycle activity in periinfarction myocardium. Modern Pathology 24 (Supplement 1):80A(2011).

52. Cappel J, Findeis-Hosey JJ, McMahon LA,Yang Q, Xu Hand Li F. MASH1: A specific immunohistochemical marker for high

grade neuroendocrine tumors of the lung. Modern Pathology 24 (Supplement1):406A (2011).

53. Mao W, Lu Y, You T, Li F and Xu H.Enhancement of Foxo proteins suppressing NaV1.5 expression by reactive oxygen

species in chronic ischemic heart disease. Circulation 124:A13459(2011).

54. Bo Y, Xu H, Li F. Cardiac specific deletion of adenomatous polyposis coli promotes cardiomyocyte hyperplasia.Circulation 124:A13121 (2011).

55. Ye J, Fiscella J, Honnons S, McMAhonLA,Yang Q,Li F and Xu H. PAX8 is useful in discriminating metastatic endometrioid

carcinoma even with infrequent TTF-1 and napsin A positivity from primary lung adenocarcinoma. Modern Pathology 25 (Supplement 2):493A (2012).

56. Cai B, Mao W, Tao, Y, Li F and Xu H.Cardiac deletion of Foxo1 leads to shortening of QRS by enhancing NaV1.5 expression and Na+currents in adult mice. Circulation 126: A13336 (2012).

57. Bo Y, Xu H, and Li F. Cardiac deletion of Brg1 chromatin remodeling ATPase causes dilated cardiomyopathy. Circulation 126:A17882, 2012.

58. Bo Y, Xu H, and Li F. Canonical Wnt/beta-catenin signaling during late embryonic heart development. Circulation

126:A17882, 2012.

59. Ren B, McMahon L, Yang Q, Wang N,Rothberg P, Zhou Z, Li L and Xu H. ALK protein expression correlates with ALK

rearrangement, but not increased ALKcopy number in lung adenocarcinomas. Modern Pathology 26 (Supplement 2):465A (2013).

60. Ye B, Hou N, Xiao L, XuH, and Li F.Assessment of oxidative DNA double strand break and Rrepair in cardiomyocytes.

Circulation Research. 2013;113:A265.

61. Hou N, Ye B, Xiao L, Xu H, and Li F.Tcf7l2 expression by insulin and high glucose. Circulation Research.

2013;113:A287.

62. Xiao L, Bai H, Boyer J, Ye B, Hou N,Xu H, and Li F. Tcf7l2 expression and isoform switching in mouse hearts.

Circulation Research. 2013;113:A293.

63.Wang N, Cai B, Li X,Lu Y, Ye B, Li F and Xu H. β-Catenin inhibition of NaV1.5 requires both TCF4 and FoxO1 in

cardiomyocytes. Circulation (2013).




受邀陈述:

1. Differential expression of voltage-gated K+ channel subunits and functional K+ channels during postnatal development. American Heart Association-68th Scientific Sessions, November, 1995 (Los Angeles, CA).
2. Molecular correlates of functional Ito and IK channels in rat ventricular myocytes probed with K+ channel toxins and antisense oligonucleotides. American Heart Association-70th Scientific Sessions, November, 1997 (Orlando, FL).
3. Functional knockout of the cardiac transient outward K+ current in mice expressing a dominant negative voltage-gated K+ channel (Kv4) a subunit. Biophysical Society-Forty-Second Annual Meeting, February, 1998 (Kansas, MO).
4. Functional knockout of the atrial transient outward K+ current in mice expressing a dominant negative Kv4 a subunit. American Heart Association-71th Scientific Sessions, November, 1998 (Dallas, TX).
5. Two distinct components of the slowly inactivating K+ current, IK,slow in mouse ventricular myocytes: a role for Kv2 a subunits. American Heart Association-72th Scientific Sessions, November, 1999 (Atlanta, GA).
6. The impact of chest imaging on the pathologic diagnosis of pulmonary, mediastinal, and pleural disease. United States and Canadian Academy of Pathology, 93rd Annual meeting, 2004 (Vancouver, BC. Canada).
7. K homology domain containing protein overexpressed in cancer (KOC) is highly expressed in small and large cell neuroendocrine carcinomas but not in carcinoid tumors of the lung. USCAP 96th annual meeting, 2007 (San Diego, CA).
8. Reactive Oxygen Species-Induced p90 Ribosomal S6 Kinase Activation Prolongs Cardiac Repolarization via Inhibiting Voltage-Gated Outward K+ Currents. Upstate New York Cardiac Electrophysiology Society17th Annual Meeting, 2007 (Rochester, NY).
9. KOC, TTF-1 and CDX2 discriminate small cell carcinoma from carcinoid and pancreatic endocrine tumor metastasized to the liver. Will be presented in USCAP 97th annual meeting, 2008 (Denver, CO).

受邀演讲:

1. Molecular dissection of cardiac repolarization. Soochow University Medical School, Suzhou, P.R. China. September 24, 2002.
2. Molecular mechanisms underlying cardiac repolarization. Cardiovascular Research Institute, University of Rochester Medical Center, USA. February 21, 2007.
3. Idiopathic pulmonary fibrosis. Chinese Pathology Society’s Annual Meeting at Chengdu, P.R. China. April 20-23, 2007.
4. Idiopathic pulmonary fibrosis-UIP. First Affiliated Hospital, Soochow University Medical School, Suzhou, P.R. China. April 26, 2007.

喻明芙 职称:病理医师 擅长:外科、细胞病理 单位:Johnson Memorial Hospital 病理科

Johnson Memorial Hospital, Stafford Springs, CT,病理临床工作经历,2005.07-2005.11 病理医师 Manchester Memorial Hospital, Manchester, CT2005.01-2009.12 病理医师 Quest Diagnostics, Wallingford, CT

2010.01-至今 病理医师/实验室主任 Johnson Memorial Hospital, Stafford Springs, CT

医学训练

1984-1985 外科住院医师 重庆解放军324医院

2000-2001 病理学住院医师 Truman Medical Center, University of Missouri at Kansas City, Kansas, MO

2001-2003 解剖病理学住院医师 Barnes-Jewish Hospital, Washington University, St. Louis, MO

2003-2004 外科病理学专科训练 Hartford Hospital, Hartford, CT

2004-2005 细胞病理学专科训练 Hartford Hospital, Hartford, CT

医学教育

1979--1984 M.D. 中国重庆第三军医大学军医专业

1985--1988 M.S. 中国重庆第三军医大学病理生理学专业

专业资格及执照

American Board of Pathology, Board certified in Anatomic Pathology in 2004年7月

American Board of Pathology, Board certified in 细胞病理学 in 2005年9月

State of Connecticut, license for physicians and surgeons 美国康涅狄格州行医执照

科研及教学经验

1988-1990 助教 重庆第三军医大学病理生理学教研室

1990-1993 博士后 美国密执安州立大学大动物系Department of Large Animal Clinical Sciences, Michigan State University, East Lansing, MI, USA

1997-1998 研究员 美国华盛顿大学Barnes-Jewish医院呼吸及急救医学系 Department of Respiratory and Critical Care Medicine, St. Louis, MO

1998-2000 科学家 美国密苏里州孟三都公司 (Monsanto Company)

部分发表文章

1. Yu, M. F., Ritter, J. R., Wang, H. L. (2004). Aberrant expression of g-catenin during colorectal tumorigenesis: lack of nuclear localization. Arch Pathol Lab Med 128: 143-144. (Abstract)

2. Kahn L. E., Doshi P. D., McGarity K. L., Yu M. F., Bono C. P., Lie W. R., Rankin A. M., Smidt M. L.,Streeter P. R., Klein B. K., Welply J. K., Woulfe S. L. (2002). Characterization of dendritic cells generated in vivo by an E. coli derived chimeric dual receptor agonist. Med Sci Monit. 8: BR504-14.

3. Yu, M. F., Gorenne, I., Su, X., Moreland, R. S., and Kotlikoff, M. I. (1998). Sodium hydrosulfite contractions of smooth muscle are calcium and myosin phosphorylation independent, Am J Physiol 275, L976-82.

4. Wang, Q., Wang, Y. X., Yu, M., and Kotlikoff, M. I. (1997). Ca2+-activated Cl- currents are activated by metabolic inhibition in rat pulmonary artery smooth muscle cells, Am J Physiol 273, C520-30.

5. Adda, S., Fleischmann, B. K., Freedman, B. D., Yu, M., Hay, D. W., and Kotlikoff, M. I. (1996). Expression and function of voltage-dependent potassium channel genes in human airway smooth muscle, J Biol Chem 271, 13239-43.

6. Yu, M. F., Ewaskiewicz, J. I., Adda, S., Bailey, K., Harris, V., Sosnoski, D., Tomasic, M., Wilson, J., and Kotlikoff, M. I. (1996). Gene transfer by adenovirus in smooth muscle cells, Respir Physiol 105, 155-62.

7. Olszewski, M. A., Robinson, N. E., Yu, M. F., and Derksen, F. J. (1995). Effects of hydrogen peroxide on isolated trachealis muscle of horses, Am J Vet Res 56, 1479-85.

8. Wang, Z. W., Yu, M. F., Robinson, N. E., and Derksen, F. J. (1995). Acetylcholine release from airway cholinergic nerves in horses with heaves, an airway obstructive disease, Am J Respir Crit Care Med 151, 830-5.

9. Wang, Z. W., Yu, M. F., and Robinson, N. E. (1995). Prejunctional muscarinic autoreceptors on horse airway cholinergic nerves, Life Sci 56, 2255-62.

10. Yu, M. F., Wang, Z. W., Robinson, N. E., and Derksen, F. J. (1994). Modulation of bronchial smooth muscle function in horses with heaves, J Appl Physiol 77, 2149-54.

11. Yu, M. F., Wang, Z., Robinson, N. E., and Leblanc, P. H. (1994). Inhibitory nerve distribution and mediation of NANC relaxation by nitric oxide in horse airways, J Appl Physiol 76, 339-44.

12. Wang, Z. W, Robinson, N. E., and Yu, M. F. (1994). PGE2 inhibits acetylcholine release from cholinergic nerves in canine but not equine airways, Prostaglandins Leukot Essent Fatty Acids 51, 347-55.

13. Wang, Z., Robinson, N. E., and Yu, M. F. (1993). ACh release from horse airway cholinergic nerves: effects of stimulation intensity and muscle preload, Am J Physiol 264, L269-75.

14. Yu, M. F., Wang, Z., and Robinson, N. E. (1993). Prejunctional alpha 2-adrenoceptors inhibit acetylcholine release from cholinergic nerves in equine airways, Am J Physiol 265, L565-70.

15. Yu, M. F., Robinson, N. E., Wang, Z., and Derksen, F. J. (1993). Independent modulation of horse airway smooth muscle by epithelium and prostanoids, Respir Physiol 93, 279-88.

16. Killingsworth, C. R., Yu, M. F., and Robinson, N. E. (1992). Evidence for the absence of a functional role for muscarinic M2 inhibitory receptors in cat trachea in vivo: contrast with in vitro results, Br J Pharmacol 105, 263-70.

17. Wang, Z., Yu, M., Robinson, N. E., Broadstone, R. V., LeBlanc, P. H., and Derksen, F. J. (1992). Exogenous but not endogenous PGE2 modulates pony tracheal smooth muscle contractions, Pulm Pharmacol 5, 225-31.

18. Yu, M., Wang, Z., Robinson, N. E., and Derksen, F. J. (1992). The inhibitory effect of furosemide on the contractile response of equine trachealis to cholinergic nerve stimulation, Pulm Pharmacol 5, 233-8.

19. Yu, M., Robinson, N. E., Wang, Z., and Derksen, F. J. (1992). Muscarinic receptor subtypes in equine tracheal smooth muscle, Vet Res Commun 16, 301-10.

岳长军 职称:资深病理医生 擅长:血液病理、遗传病理 单位:Medical Director, LabCorp-Covance Clinical Trials, Los Angeles 病理科

1979年-1984年 就读于上海第二军医大学海军医学系,84年获医学学士学位。同年考入北京军事医学科学院,师从秦伯益院士从事新药评价研究,87年获医学硕士学位,后留院工作。

1992年 赴美留学,就读于南加州大学药学院分子药理毒理学系,1997年毕业并获博士学位。

1998年 通过美国国家医学博士认证资格考试,同年进入Harbor-UCLA Medical Center 病理系做住院医生。

2001年 获准提前毕业并进入UCLA Medical Center/Medical School 做血液病理Fellow,师从世界著名病理学家Jonathan Said 教授。期间并师从世界最著名的淋巴瘤专家Elaine Jaffe 博士(美国国立卫生研究院NIH)学习淋巴瘤诊断技术。2002年毕业。

2000年至今 持加州行医执照;2006年至今持北卡罗来那州行医执照。

2002年 通过美国国家病理医生认证资格考试(Board Certified in AP, CP)

2004年 通过美国国家血液病理医生认证资格考试 (Board Certified in

Hematology/Pathology)

2007年 通过美国国家分子遗传病理医生认证资格考试(Board Certified in Molecular Genetic Pathology),成为首批美国国家认证的分子遗传病理学医生。

2002年-2003年 在加州首府(Sacramento)Sutter General Hospital, Mercy General Hospital, Sutter Memorial Hospital and Roseville General Hospital 任血液学病理医生。

2003年至今 在全美最大的医学诊断集团(LabCorp)Integrated Oncology 部门任资深血液病理医生及资深分子遗传病理学医生和医学部副主任。同时任职Assistant Clinical Professor于Harbor-UCLA Medical Center。

近期发表的文章:

Zhao, X, Yue, C: Gastrointestinal Stromal Tumor. Journal of Gastrointestinal Oncology, 2012, 3(3): 189-208.

Qing X, Sun N, French S, Yue C: Oral and Extraoral Plasmablastic Lymphoma: Similarities and Differences in Clinicopathologic Characteristics. AJCP, 2011, 135:
Qing X, Sun N, Chang E, French S, Ji P, Yue C: Plasmablastic lymphoma may occur as a high-grade transformation from plasmacytoma. Exp Mol Pathol. 2011 Feb ;90(1):85-90.
Lu G, Kong Y, Yue, C: Genetic and immunophenotypic profile of IGH rearrangement detected by fluorescence in situ hybridization in 149 cases of B-cell chronic lymphocytic leukemia, Cancer Genetics and Cytogenetics, Volume 196, Issue 1, 1 January 2010, Pages 56-63

美国专利:
US PATENT: YUE, CJ, SATYEDEV, R AND ENDLICH, M: DOUBLE-LABELING IMMUNOSTAINING METHOD FOR DIAGNOSING B-CELL LYMPHOMAS, filed on Friday, July 28, 2006 (Ref. No. 034702/309853)

近期会议报告及讲座:
Yue, C: A Practical Approach to T-Cell lymphoma. Grand Rounds at Harbor-UCLA Medical Center; Department of Pathology, April 5, 2013.
Yue, C: Microsatellite Instability and Lynch Syndrome. Grand Rounds at Harbor-UCLA Medical Center; Department of Pathology, February 24, 2012.
Yue, C. : Cutaneous Hodgkin Lymphoma. Case presentation. 15th Annual Meeting of the European Association for Hematopathology, October 27-29, 2011 – Los Angeles, USA
Yue, CJ: Updates on Diagnosis and Classification of Thymoma, Southern California Kaiser Permanente Teleconference, May 17, 2011.
Yue, CJ: Application of Molecular Genetic Pathology in Hematology, Part II, Teleconference Network of Texas’ (TNT), UT Health Science Center at San Antonio, April 19, 2011.
Walavalkar V, Yue CJ, Radomski J, and Zhao X: Diffuse Large B Cell Lymphoma with Lack of Surface Immunoglobulin Light Chain Expression by Flow Cytometry: Morphology, Flow Cytometry, and Immunohistochemistry. AJCP 2010; 134(suppl): 1-58
Yue, CJ: Application of Molecular Genetic Pathology in Diagnosis and Prognosis of Hematologic Malignancy, BIT’s 1st Annual Tetra-Congress of MolMed-2010, Shanghai, China, November 11, 2010
Yue, CJ: Application of Molecular Genetic Pathology in Hematology, Part I, Teleconference Network of Texas’ (TNT), UT Health Science Center at San Antonio, April 20, 2010.
Lu G, Yue C. IgH rearrangement by FISH in B-cell chronic lymphocytic leukemia frequently involves t(14;19)(q32;q13.2) and is associated with CD38 expression. 2009 American College of Medical Genetics Annual Meeting, March 25-29, 2009, Tampa, Florida
Yue, C. : Angiocentric Large B cell lymphoma. Case presentation. 14th Annual Meeting of the European Association for Hematopathology, September 20-25, 2008 – Bordeaux, France
Yue, C: Molecular Genetic Pathology Overview. Grand Rounds at Harbor-UCLA Medical Center; Department of Pathology, January 25, 2008.
Yue, CJ: Diagnosis and Classification of Thymoma, Teleconference Network of Texas’ (TNT), UT Health Science Center at San Antonio, April 15, 2008.
Yue C, Hibbard MK, Savala J, O'Malley DP, Dhillon S. Chronic Eosinophilic Leukemia with t(4;22) without involvement of BCR. Case presentation. Society for Hematopathology/ European Association for Hematopathology Annual Workshop, Indianapolis. November 2007.
O’Malley DP, Hibbard MK, Savala J, Jiang S, McMasters R, Chen WW, Yue C, Stroup R, Zepeda H. BCR/JAK2 fusion myeloproliferative neoplasm. Platform Presentation. Society for Hematopathology/ European Association for Hematopathology Annual Workshop, Indianapolis. November 2007.
Chen WW, Lu G, Jiang S, Yue C, McMasters R, Savala J, O’Malley DP. JAK2 V617F mutation in chronic neutrophilic leukemia. Case presentation. Society for Hematopathology/ European Association for Hematopathology Annual Workshop, Indianapolis. November 2007.
Yue, CJ, Anthony, A, and Lu, G: THE SUBSTANTIALLY HIGH FREQUENCY AND STRONG CORRELATION OF IGH REARRANGEMENT BY FISH WITH CD38 EXPRESSION BY FLOW CYTOMETRY IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA. XIII. Meeting of the European Association for Hematopathology, October 7 - 12, 2006, Hilton Vienna, Austria
Yue CJ, Anthony, A and Bolton, H: T CELL MARKER CHANGES IN PERIPHERAL T CELL LYMPHOMAS BY FLOW CYTOMETRY ANALYSIS. USCAP 96th Annual Meeting, San Diego, CA, March 24-30, 2007
Yue, CJ: Common Pitfalls in Flow Cytometry Diagnosis, Teleconference Network of Texas’ (TNT), UT Health Science Center at San Antonio, September 19, 2006.
Yue, CJ: The Role of Immunohistochemistry in Tumor Diagnosis, Grand Rounds at Harbor-UCLA Medical Center; April 29, 2005.

郑刚 职称:病理科副主任 助理教授 擅长:血液、分子病理 单位:约翰霍普金斯医院 病理科

郑刚, MD,PhD,现在职称:助理教授,病理学。专业方向:血液病理学,分子病理学。北京医科大学本科,美国Case Western Reserve University博士,美国哈佛大学医学院博士后。2009年进入美国约翰霍普金斯医院病理系做解剖/临床病理医生。现为美国病理学院会员,美国临床病理学会会员, 美国血液协会会员,以及美国分子病理协会会员。

PUBLICATIONS

1.  Zhang T, Zheng G. Effects of Lycium Barbarum extracts on prevention of micronuclear formation in bone marrow. Journal of eugenics. 1997;8(2):74-75. 
2.  Han M, Zheng G, Shou CC, construction of expression vector of cDNA encoding p185 extracellular domains. Ningxia Medical Journal. 2001;23(3): 131-133. 
3. Zheng G, Yang YC. ZNF76, a novel transcriptional repressor targeting TATA-binding protein, is modulated by sumoylation. The Journal of biological chemistry. 2004;279(41):42410-21.
4. Zheng G, Yang YC. Sumoylation and acetylation play opposite roles in the transactivation of PLAG1 and PLAGL2. The Journal of biological chemistry. 2005;280(49):40773-81. 
5. Zheng G, Yang YC. Acetylation and alternative splicing regulate ZNF76-mediated transcription. Biochemical and biophysical research communications. 2006;339(4):1069-75. 
6. Zhang K, Zheng G, Yang YC. Stability of Nmi protein is controlled by its association with Tip60. Molecular and cellular biochemistry. 2007;303(1-2):1-8. 
7. Zheng G, Ning J, Yang YC. PLAGL2 controls the stability of Pirh2, an E3 ubiquitin ligase for p53. Biochemical and biophysical research communications. 2007;364(2):344-50.
8. Ning J, Zheng G, Yang YC. Tip60 modulates PLAGL2-mediated transactivation by acetylation. Journal of cellular biochemistry. 2008;103(3):730-9. 
9. Zheng G, Schweiger MR, Martinez-Noel G, Zheng L, Smith JA, Harper JW, Howley PM. Brd4 regulation of papillomavirus protein E2 stability. Journal of virology. 2009;83(17):8683-92.
10. Park JK, Gelber AC, Zheng G, McDevitt MA, Gocke CD, Baer AN. Large-vessel vasculitis as an early manifestation of chronic myelomonocytic leukemia. Journal of clinical oncology. 2011;29(20):e601-3. 
11. Zheng G, Schmieg J, Guan H, Ali SZ. Blastic plasmacytoid dendritic cell neoplasm: cytopathologic findings. Acta cytologica. 2012;56(2):204-8.
12. Zheng G, Chaux A, Sharma R, Netto G, Caturegli P. LMP2, a novel immunohistochemical marker to distinguish renal oncocytoma from the eosinophilic variant of chromophobe renal cell carcinoma. Experimental and molecular pathology. 2013;94(1):29-32.
13. Zheng G, Ettinger DS, Maleki Z. Utility of the quantitative Ki-67 proliferation index and CD56 together in the cytologic diagnosis of small cell lung carcinoma and other lung neuroendocrine tumors. Acta cytologica. 2013;57(3):281-90. [SI/QI]
14. Zheng G, Martignoni G, Antonescu C, Montgomery E, Eberhart C, Netto G, Taube J, Westra W, Epstein JI, Lotan T, Maitra A, Gabrielson E, Torbenson M, Iacobuzio-Donahue C, Demarzo A, Shih Ie M, Illei P, Wu TC, Argani P. A broad survey of cathepsin K immunoreactivity in human neoplasms. American journal of clinical pathology. 2013;139(2):151-9.
15. Carter J, Tseng LH, Zheng G, Dudley J, Illei P, Gocke CD, Eshleman JR, Lin MT. Non-p.V600E BRAF Mutations Are Common Using a More Sensitive and Broad Detection Tool. American journal of clinical pathology. 2015;144(4):620-8. 
16. Haley L, Tseng LH, Zheng G, Dudley J, Anderson DA, Azad NS, Gocke CD, Eshleman JR, Lin MT. Performance characteristics of next-generation sequencing in clinical mutation detection of colorectal cancers. Modern pathology. 2015;28(10):1390-9. 
17. Lin MT, Tseng LH, Dudley JC, Riel S, Tsai H, Zheng G, Pratz KW, Levis MJ, Gocke CD. A Novel Tandem Duplication Assay to Detect Minimal Residual Disease in FLT3/ITD AML. Molecular diagnosis & therapy. 2015;19(6):409-17. 
18. Zheng G, Tseng LH, Chen G, Haley L, Illei P, Gocke CD, Eshleman JR, Lin MT. Clinical detection and categorization of uncommon and concomitant mutations involving BRAF. BMC cancer. 2015;15:779. 
19. Allison DB, Lilo MT, Geddes S, Pallavajjalla A, Askin F, Gabrielson E, Zheng G, Li QK. Detection of PIK3CA mutations, including a novel mutation of V344G in exon 4, in metastatic lung adenocarcinomas: A retrospective study of 115 FNA cases. Cancer cytopathology. 2016 Jul;124(7):485-92. 
20. Argani P, Lee J, Netto GJ, Zheng G, Tseh-Lin M, Park BH. Frequent BRAF V600E Mutations in Metanephric Stromal Tumor. The American journal of surgical pathology. 2016; 40(5):719-22. 
21. Gondek LP*, Zheng G*, Ghiaur G, DeZern AE, Matsui W, Yegnasubramanian S, Lin MT, Levis M, Eshleman JR, Varadhan R, Tucker N, Jones R*, Gocke CD*. Donor cell leukemia arising from clonal hematopoiesis after bone marrow transplantation. Leukemia. 2016 Sep;30(9):1916-20. * equal contribution
22. Zheng G, Tsai H, Tseng LH, Illei P, Gocke CD, Eshleman JR, Netto G, Lin MT. Test feasibility of next generation sequencing assays in clinical mutation detection of small biopsy and fine needle aspiration specimens. Am J Clin Pathol. 2016 May;145(5):696-702. 
23. Zheng G*, Lin MT*, Lokhandwala P, Beierl K, Netto G, Gocke CD, Eshleman JR, McCarthy E, Illei P. Clinical mutational profiling of bone metastases of lung and colon carcinoma and malignant melanoma using nextゞeneration sequencing. Cancer cytopathology. 2016 Oct;124(10):744-753. *equal contribution
24. Mature and Immature Solid Teratomas Involving Uterine Corpus, Cervix, and Ovary. Stolnicu S, Szekely E, Molnar C, Molnar CV, Barsan I, D'Alfonso V, Moldovan C, Zheng G, Ronnett BM, Soslow RA. Int J Gynecol Pathol. 2016 Sep 15. [Epub ahead of print] 
25. Analytical Validation of Androgen Receptor Splice Variant 7 Detection in a Clinical Laboratory Improvement Amendments (CLIA) Laboratory Setting. Lokhandwala PM, Riel SL, Haley L, Lu C, Chen Y, Silberstein J, Zhu Y, Zheng G, Lin MT, Gocke CD, Partin AW, Antonarakis ES, Luo J, Eshleman JR. J Mol Diagn. 2017 Jan;19(1):115-125. 
26. Coronary Plaque Progression and Regression in Asymptomatic African American Chronic Cocaine Users With Obstructive Coronary Stenoses: A Preliminary Study. Sandfort V, Bluemke DA, Vargas J, Brinker JA, Gerstenblith G, Kickler T, Zheng G, Li J, Chen S, Lai H, Fishman EK, Lai S. J Addict Med. 2017 Mar/Apr;11(2):126-137. 
27. Clinical mutational profiling of 1006 lung cancers by next generation sequencing. Illei P, Belchis D, Nguyen D, De Marchi F, Haley L, Riel S, Beierl K, Zheng G, Brahmer J, Askin F, Gocke C, Eshleman J, Forde P, Lin MT. 2017. Oncotarget, accepted. 
28. The clinical utility of the heparin neutralization assay in the diagnosis of heparin-induced thrombocytopenia. Zheng G*, Streiff MB, Takemoto CM, Bynum J, Gelwan E, Jani J, Judge D, and Kickler T.  Clinical and applied thrombosis/hemostasis. 2017, accepted. * Corresponding author

曹跃华 职称:主任医师 擅长:妇科、非妇科、穿刺细胞学 单位:多伦多总医院 病理科

医学硕士,就职于加拿大多伦多大学医疗联合体多伦多全科医院,细胞病理诊断技术专家(美国临床病理学会资格认证)。为美国细胞病理学会(ASC)、美国临床病理学会(ASCP)及加拿大医学实验科学学会(CSMLS)会员,曾为中国医疗保健国际交流促进会海外顾问。主编最新出版了《细胞病理学常见病例诊断及鉴别诊断》,曾主编并再版了《细胞病理学诊断图谱及实验技术手册》,参加主编出版了《实用妇科细胞学教程》,副主编出版了《女性生殖系统疑难病例--临床病理讨论》。毕业于加拿大米切尔应用医学研究院细胞病理诊断专业及哈佛大学医学院的高级细胞病理诊断专业培训班。为美国细胞病理学会(ASC)、美国临床病理学会(ASCP)及加拿大医学实验科学学会(CSMLS)会员。家中的亲人曾经患癌症或因癌症去世, 从而在肿瘤的最新信息研究, 宣传,教育和肿瘤病人的健康管理方面做了大量的探索, 励志帮助更多的肿瘤病人对抗癌症,在健康路上携手同行。现为加拿大癌症学会会员及义务教育大使,加拿大资深健康教育及管理专家,加拿大康福心理健康协会董事及社区心理健康教育大使,加拿大骨质疏松学会骨健康教育大使。